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Renalase Protects against Ischemic AKI
- Source :
- Journal of the American Society of Nephrology. 24:445-455
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- Elevated levels of plasma catecholamines accompany ischemic AKI, possibly contributing the inflammatory response. Renalase, an amine oxidase secreted by the proximal tubule, degrades circulating catecholamines and reduces myocardial necrosis, suggesting that it may protect against renal ischemia reperfusion injury. Here, mice subjected to renal ischemia reperfusion injury had significantly lower levels of renalase in the plasma and kidney compared with sham-operated mice. Consistent with this, plasma NE levels increased significantly after renal ischemia reperfusion injury. Furthermore, renal tubular inflammation, necrosis, and apoptosis were more severe and plasma catecholamine levels were higher in renalase-deficient mice subjected to renal ischemia reperfusion compared with wild-type mice. Administration of recombinant human renalase reduced plasma catecholamine levels and ameliorated ischemic AKI in wild-type mice. Taken together, these data suggest that renalase protects against ischemic AKI by reducing renal tubular necrosis, apoptosis, and inflammation, and that plasma renalase might be a biomarker for AKI. Recombinant renalase therapy may have potential for the prevention and treatment of AKI.
- Subjects :
- Male
medicine.medical_specialty
Necrosis
Ischemia
Gene Expression
Apoptosis
Inflammation
Biology
urologic and male genital diseases
Mice
Norepinephrine
Internal medicine
medicine
Animals
Humans
RNA, Messenger
Phentolamine
Monoamine Oxidase
Adrenergic alpha-Antagonists
Renalase
Mice, Knockout
Kidney
Macrophages
Acute kidney injury
General Medicine
Acute Kidney Injury
Kidney Tubular Necrosis, Acute
medicine.disease
Recombinant Proteins
Mice, Inbred C57BL
Basic Research
Endocrinology
medicine.anatomical_structure
Neutrophil Infiltration
Nephrology
Reperfusion Injury
Catecholamine
Inflammation Mediators
medicine.symptom
Reperfusion injury
medicine.drug
Subjects
Details
- ISSN :
- 10466673
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of the American Society of Nephrology
- Accession number :
- edsair.doi.dedup.....da37192a88a05240fb8472858872870b