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Opossum kidney contains a functional receptor for the Escherichia coli heat-stable enterotoxin
- Source :
- Biochemical and biophysical research communications. 159(1)
- Publication Year :
- 1989
-
Abstract
- The Escherichia coli heat-stable enterotoxin (ST1 or STa) binds to specific receptors on mammalian intestinal brush border membranes, and stimulates guanylate cyclase in those membranes. We have found a similar signal transduction system in brush border membranes prepared from kidney cortex of the American opossum (Didelphis virginiana, and in a cell line (OK cell) derived from that tissue. Activation of guanylate cyclase by ST1 is therefore not limited to intestinal cells. Furthermore, since it is unlikely that ST1 which is produced in the intestinal lumen, would have access to kidney receptors, this suggests the existence of an endogenous peptide resembling ST1, at least in marsupials.
- Subjects :
- Brush border
Didelphis
Receptors, Peptide
Swine
Bacterial Toxins
Biophysics
Receptors, Enterotoxin
Receptors, Cell Surface
Enterotoxin
Kidney
Biochemistry
Binding, Competitive
Cell Line
Enterotoxins
Opossum
Heat-stable enterotoxin
Animals
Intestinal Mucosa
Receptor
Molecular Biology
Cyclic GMP
biology
Microvilli
Escherichia coli Proteins
Kidney metabolism
Cell Biology
Guanylate cyclase 2C
Opossums
biology.organism_classification
Molecular biology
Enzyme Activation
Receptors, Guanylate Cyclase-Coupled
Guanylate Cyclase
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 159
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biochemical and biophysical research communications
- Accession number :
- edsair.doi.dedup.....da27bc016535c5af514ed58c6a317fe3