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Absolute stereochemical determination of 1,2‐diols via complexation with dinaphthyl borinic acid
- Source :
- Chirality. 32:817-823
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Rapid derivatization of chiral 1,2-diols with dinaphthyl borinic acid (DBA) leads to a cyclic boronate, enabling the absolute stereochemical prediction via exciton-coupled circular dichroic (ECCD) of the naphthyl groups. Aryl- and alkyl-substituted 1,2-diols derivatized with DBA yield a predictable ECCD, which is also in agreement with theoretical predictions derived from computationally minimized structures.
- Subjects :
- inorganic chemicals
Pharmacology
010405 organic chemistry
organic chemicals
Aryl
Organic Chemistry
010402 general chemistry
01 natural sciences
Catalysis
0104 chemical sciences
Analytical Chemistry
chemistry.chemical_compound
chemistry
Computational chemistry
Yield (chemistry)
Drug Discovery
polycyclic compounds
Derivatization
Chirality (chemistry)
Borinic acid
Spectroscopy
Subjects
Details
- ISSN :
- 1520636X and 08990042
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Chirality
- Accession number :
- edsair.doi.dedup.....da26e903a09407ff3f08277ae5754561