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First Insights into the Gut Microbiota of Mexican Patients with Celiac Disease and Non-Celiac Gluten Sensitivity
- Source :
- Nutrients, Volume 10, Issue 11, Nutrients, Vol 10, Iss 11, p 1641 (2018)
- Publication Year :
- 2018
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2018.
-
Abstract
- Gluten-related disorders (GRDs) are common chronic enteropathies and increasing evidence suggests an involvement of the gut microbiota. We examined the gut microbiota in Mexican people afflicted with GRDs. Ultra-high-throughput 16S marker sequencing was used to deeply describe the duodenal and fecal microbiota of patients with celiac disease (CD, n = 6), non-celiac gluten sensitivity (NCGS, n = 12), and healthy subjects (n = 12) from our local area. Additionally, we also investigated the changes in gut microbiota after four weeks on a gluten-free diet (GFD) in a subset of patients from whom paired samples were available. Despite a high inter-individual variability, significant differences in various microbial populations were identified. The linear discriminant analysis (LDA) effect size (LEfSe) method revealed that the genus Actinobacillus and the family Ruminococcaceae were higher in the duodenal and fecal microbiota of NCGS patients, respectively, while Novispirillum was higher in the duodenum of CD patients (p &lt<br />0.05, LDA score &gt<br />3.5). Interestingly, paired samples from NCGS patients showed a significant difference in duodenal Pseudomonas between the baseline period (median: 1.3%<br />min/max: 0.47&ndash<br />6.8%) and the period after four weeks on GFD (14.8%<br />2.3&ndash<br />38.5%, p &lt<br />0.01, Wilcoxon signed-rank test). These results encourage more research on GRDs in M&eacute<br />xico.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Glutens
Duodenum
Biopsy
Genus Actinobacillus
lcsh:TX341-641
Disease
Gut flora
Gastroenterology
digestive system
Article
Young Adult
03 medical and health sciences
Paired samples
Novispirillum
gluten-free diet
RNA, Ribosomal, 16S
Pseudomonas
Internal medicine
medicine
Humans
Mexico
Aged
Nutrition and Dietetics
Bacteria
biology
gut microbiota
business.industry
Healthy subjects
Middle Aged
medicine.disease
biology.organism_classification
Gastrointestinal Microbiome
030104 developmental biology
medicine.anatomical_structure
Female
business
lcsh:Nutrition. Foods and food supply
Non-celiac gluten sensitivity
gluten-related disorders
celiac disease
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....da25fc2fd50f3670e143e70e9d2ea3ea
- Full Text :
- https://doi.org/10.3390/nu10111641