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Gene expression profiling in human lung fibroblast following cadmium exposure
- Source :
- Food and Chemical Toxicology. 46:1131-1137
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Cadmium is a naturally occurring metallic element with food and smoking being the main sources of exposure in the non-occupationally exposed population. Chronic exposure to cadmium leads to tumors in a number of tissues including lung. In the present study we investigated genes whose expression is modified by Cd exposure in human lung fibroblast WI38-VA13 cells. We employed a cDNA microarray hybridization method to identify changes in the gene expression profile. Thirty five genes were identified as cadmium-responsive. Their level of expression differed significantly from controls (significance analysis of microarray; SAM, q
- Subjects :
- inorganic chemicals
Microarray
chemistry.chemical_element
Biology
Toxicology
Cell Line
Gene expression
Humans
Lung
Gene
DNA Primers
Oligonucleotide Array Sequence Analysis
Cadmium
Base Sequence
Reverse Transcriptase Polymerase Chain Reaction
Gene Expression Profiling
Nucleic Acid Hybridization
General Medicine
Fibroblasts
Cell cycle
Molecular biology
Gene expression profiling
chemistry
Immunology
Signal transduction
DNA microarray
Food Science
Subjects
Details
- ISSN :
- 02786915
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Food and Chemical Toxicology
- Accession number :
- edsair.doi.dedup.....da1c9207e55617d62089a296942ef7cc