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Exposome-wide association study of semen quality: Systematic discovery of endocrine disrupting chemical biomarkers in fertility require large sample sizes
- Source :
- Environment International, Vol 125, Iss, Pp 505-514 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Objectives: Exposome-wide association studies (EWAS) are a systematic and unbiased way to investigate multiple environmental factors associated with phenotype. We applied EWAS to study semen quality and queried the sample size requirements to detect modest associations in a reproductive cohort. Study design and setting: We conducted 1) a multivariate EWAS of 128 endocrine disrupting chemicals (EDCs) from 15 chemical classes measured in urine/serum relative to 7 semen quality endpoints in a prospective cohort study comprising 473 men and 2) estimated the sample size requirements for EWAS etiologic investigations. Results: None of the EDCs were associated with semen quality endpoints after adjusting for multiple tests. However, several EDCs (e.g., polychlorinated biphenyl congeners 99, 105, 114, and 167) were associated with raw p
- Subjects :
- Adult
Male
Exposome
Multivariate statistics
010504 meteorology & atmospheric sciences
media_common.quotation_subject
Fertility
Endocrine Disruptors
010501 environmental sciences
01 natural sciences
Article
Young Adult
Semen quality
Semen
Environmental health
Humans
Medicine
Prospective Studies
Prospective cohort study
lcsh:Environmental sciences
0105 earth and related environmental sciences
General Environmental Science
media_common
lcsh:GE1-350
business.industry
Semen Analysis
Sample size determination
Sample Size
Cohort
Environmental Pollutants
business
Biomarkers
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 01604120
- Volume :
- 125
- Database :
- OpenAIRE
- Journal :
- Environment International
- Accession number :
- edsair.doi.dedup.....da13e12da73a0dacd79939de5e2d0425