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Factors affecting sensitivity of distortion-product otoacoustic emissions to ototoxic hearing loss
- Source :
- Ear and hearing. 29(6)
- Publication Year :
- 2008
-
Abstract
- Objectives: (1) To determine the ototoxicity detection rate (sensitivity) for distortion-product otoacoustic emissions (DPOAEs) testing in adults who received ototoxic medications and experienced pure-tone threshold changes during the course of treatment; (2) to determine the extent to which DPOAE sensitivity to ototoxicity depends on the type of drug administered (platinum or antibiotic), magnitude of ototoxic threshold shifts, pre-exposure pure-tone threshold, and DPOAE data; and (3) to build a model to predict DPOAE sensitivity. Design: DPOAE and audiometric data were obtained as part of a prospective Veterans Affairs study investigating methods of ototoxicity monitoring. Data were analyzed from 90 ears of 53 subjects receiving ototoxic medications and showing significant hearing changes in at least one ear. Pure-tone threshold data were obtained at frequencies from 0.5 to 20 kHz, using 1/6-octave precision near the upper frequency limit of hearing. DPOAE data are reported for f2’s from 0.8 to 8.0 kHz in 1/6-octave increments using primary levels (L1/L2) of 65/59 dB SPL and a primary frequency ratio (f2/f1) of 1.2. Test results were evaluated at various times during drug treatment to determine whether DPOAE level changes were associated with behavioral hearing changes. Univariate and multivariate analysis techniques were used to determine factors that affected DPOAE sensitivity to ototoxic damage. Results: Of the 90 ears examined, 82 (91%) had DPOAEs that could be monitored for changes. Sixty-four of these 82 ears (78%) had DPOAEs that were reduced or absent following drug treatment. DPOAE sensitivity to ototoxicity was unrelated to the type of ototoxic drug administered. Rather, DPOAE sensitivity depended on the magnitude of postexposure hearing changes and on variables related to pre-exposure audiogram and DPOAE measurements. Behavioral hearing changes not detected by DPOAEs were small on average (
- Subjects :
- Male
medicine.medical_specialty
Distortion product
Hearing loss
Ototoxic hearing loss
Otoacoustic Emissions, Spontaneous
Antineoplastic Agents
Audiology
Sensitivity and Specificity
Carboplatin
Speech and Hearing
Ototoxicity
otorhinolaryngologic diseases
medicine
Humans
Prospective Studies
Hearing Loss
Audio frequency
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
musculoskeletal, neural, and ocular physiology
Auditory Threshold
Audiogram
Middle Aged
medicine.disease
Aminoglycosides
Otorhinolaryngology
Audiometry, Pure-Tone
Female
sense organs
medicine.symptom
Audiometry
Cisplatin
Drug Monitoring
business
Sensitivity (electronics)
Subjects
Details
- ISSN :
- 15384667
- Volume :
- 29
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Ear and hearing
- Accession number :
- edsair.doi.dedup.....d9f63892698ce7d19c26544b794b1118