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Inverse supercritical fluid extraction as a sample preparation method for the analysis of the nanoparticle content in sunscreen agents
- Source :
- Journal of chromatography. A. 1440
- Publication Year :
- 2015
-
Abstract
- We demonstrate the use of inverse supercritical carbon dioxide (scCO2) extraction as a novel method of sample preparation for the analysis of complex nanoparticle-containing samples, in our case a model sunscreen agent with titanium dioxide nanoparticles. The sample was prepared for analysis in a simplified process using a lab scale supercritical fluid extraction system. The residual material was easily dispersed in an aqueous solution and analyzed by Asymmetrical Flow Field-Flow Fractionation (AF4) hyphenated with UV- and Multi-Angle Light Scattering detection. The obtained results allowed an unambiguous determination of the presence of nanoparticles within the sample, with almost no background from the matrix itself, and showed that the size distribution of the nanoparticles is essentially maintained. These results are especially relevant in view of recently introduced regulatory requirements concerning the labeling of nanoparticle-containing products. The novel sample preparation method is potentially applicable to commercial sunscreens or other emulsion-based cosmetic products and has important ecological advantages over currently used sample preparation techniques involving organic solvents.
- Subjects :
- Nanoparticle
02 engineering and technology
01 natural sciences
Biochemistry
Chemistry Techniques, Analytical
Analytical Chemistry
Matrix (chemical analysis)
Sample preparation
Titanium
Field flow fractionation
Chromatography
Supercritical carbon dioxide
Chemistry
010401 analytical chemistry
Organic Chemistry
Extraction (chemistry)
Supercritical fluid extraction
Chromatography, Supercritical Fluid
General Medicine
021001 nanoscience & nanotechnology
Fractionation, Field Flow
0104 chemical sciences
Emulsion
Solvents
Nanoparticles
0210 nano-technology
Sunscreening Agents
Subjects
Details
- ISSN :
- 18733778
- Volume :
- 1440
- Database :
- OpenAIRE
- Journal :
- Journal of chromatography. A
- Accession number :
- edsair.doi.dedup.....d9ee9352025e771486b78948684790d7