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Effectiveness of hormonal contraception in HIV-infected women using antiretroviral therapy
- Source :
- AIDS. 29:2353-2359
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Objective: The objective of this study is to assess whether antiretroviral therapy (ART) may diminish the effectiveness of hormonal contraceptive methods. Methods: Using data from 5153 HIV-infected women followed prospectively for 1-3 years in three HIV prevention studies in Africa we compared incident pregnancy rates by contraceptive method (implant injectable oral or none) and ART use. Multivariable Cox regression models were used to determine adjusted hazard ratios (aHRs) and test interactions between each method and ART use. Results: During follow-up 9% of women ever used implants 40% used injectables and 14% used oral contraceptives; 31% of women ever used ART mostly nevirapine (75% of ART users) or efavirenz-based (15%). Among women not using contraception pregnancy rates were 13.2 and 22.5 per 100 women-years for those on and not on ART respectively. Implants greatly reduced the incidence of pregnancy among both women on ART [aHR 0.06 95% confidence interval (95% CI) 0.01-0.45] and not on ART (aHR 0.05 95% CI 0.02-0.11). Injectables (aHR 0.18 on ART and aHR 0.20 not on ART) and oral contraceptives (aHR 0.37 on ART and aHR 0.36 not on ART) also reduced pregnancy risk though by lesser degrees. ART use did not significantly diminish contraceptive effectiveness although all methods showed nonstatistically significant reduced. Conclusion: Hormonal contraceptive methods are highly effective in reducing pregnancy risk in HIV-infected women including those concurrently using ART. Studies of potential interactions between ART and contraceptives should evaluate real-world effectiveness of contraceptive methods; in this study implants were the most effective method to prevent pregnancy even during ART use. Copyright 2015 Wolters Kluwer Health Inc. All rights reserved. Copyright © 2015 Wolters Kluwer Health Inc. Unauthorized reproduction of this article is prohibited.
- Subjects :
- Adult
Male
medicine.medical_specialty
Nevirapine
Efavirenz
Adolescent
Pregnancy Rate
Immunology
Population
HIV Infections
Article
Young Adult
chemistry.chemical_compound
Pregnancy
Antiretroviral Therapy, Highly Active
Contraceptive Agents, Female
medicine
Humans
Immunology and Allergy
Longitudinal Studies
Prospective Studies
education
Gynecology
education.field_of_study
Obstetrics
business.industry
Hazard ratio
Middle Aged
medicine.disease
Pregnancy rate
Contraception
Treatment Outcome
Infectious Diseases
Anti-Retroviral Agents
chemistry
Family planning
Hormonal contraception
Africa
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 02699370
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- AIDS
- Accession number :
- edsair.doi.dedup.....d9ed26c504bf763f766938324de8dc13