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Effects of Taltrimide, an Experimental Taurine Derivative, on Photoconvulsive Response in Epileptic Patients
- Source :
- Epilepsia. 28:133-137
- Publication Year :
- 1987
- Publisher :
- Wiley, 1987.
-
Abstract
- Taltrimide is a lipophilic taurine derivative with definitive anticonvulsive effects in experimental epilepsy models. In this study, taltrimide was administered for 6 days, and the effects of the treatment on photoconvulsive response in EEG in eight epileptic patients were evaluated. Discharges provoked by intermittent photic stimulation (IPS) were increased by greater than 50% in four patients after taltrimide treatment. Only one patient had reduction of sensitivity. There was only a slight change in discharges after hyperventilation and no change in spontaneous paroxysms. The effects of taltrimide on photosensitivity appear to be rather specific. The study does not reveal anticonvulsive effects of taltrimide in humans.
- Subjects :
- medicine.medical_specialty
Taurine
Indoles
Photic Stimulation
medicine.medical_treatment
Phthalimides
Electroencephalography
03 medical and health sciences
chemistry.chemical_compound
Epilepsy
0302 clinical medicine
Oral administration
Hyperventilation
medicine
Animals
Humans
Intermittent photic stimulation
030304 developmental biology
0303 health sciences
medicine.diagnostic_test
business.industry
Brain
medicine.disease
3. Good health
Surgery
Anticonvulsant
Neurology
chemistry
Anesthesia
Anticonvulsants
sense organs
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15281167 and 00139580
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Epilepsia
- Accession number :
- edsair.doi.dedup.....d9ebe1629fe3b612071eb7ea0ad24e4d