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Second-Generation Insulin Analogues - a Review of Recent Real-World Data and Forthcoming Head-to-Head Comparisons
- Source :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona
- Publication Year :
- 2018
-
Abstract
- Altres ajuts: Editorial assistance was provided by Touch Medical Media and was funded by Sanofi. Insulin analogues play a key role in the effective management of type 2 diabetes. However, there are several behavioural barriers to appropriate early initiation of insulin therapy, despite compelling evidence supporting the benefits of this strategy in those patients for whom oral anti-diabetes agents provide insufficient control. The development of second-generation insulin analogues (insulin glargine 300 U/mL and insulin degludec) has provided physicians with agents that can provide comparable glycaemic control to first-generation insulin, but with a reduced risk of hypoglycaemia and modes of action suited to once-daily regimens. These characteristics may help overcome patient and physician concerns about early insulin use in disease management. To date, there have been no head-to-head comparisons of second-generation insulins: here we consider recent real-world evidence and the forthcoming direct comparison in the BRIGHT randomised controlled study, as presented at the recent 11 th International Conference on Advanced Technologies & Treatments for Diabetes (ATTD) 2018.
- Subjects :
- Insulin degludec
medicine.medical_specialty
Head to head
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
030209 endocrinology & metabolism
Type 2 diabetes
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Diabetes mellitus
medicine
Insulin glargine 300
Disease management (health)
Intensive care medicine
Endocrine and Autonomic Systems
Insulin glargine
business.industry
Insulin
Once-daily insulin
medicine.disease
Second-generation
business
Hypoglycaemia
Real world data
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona
- Accession number :
- edsair.doi.dedup.....d9dceae5464673a89543411644dbbe33