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DNA repair gene XRCC1 polymorphisms, smoking, and esophageal cancer risk
- Source :
- Cancer detection and prevention. 28(3)
- Publication Year :
- 2004
-
Abstract
- To investigate the effect of X-ray repair cross complementing 1 (XRCC1) genetic polymorphisms on esophageal cancer risk, we determined XRCC1 polymorphisms at codon 194 (Arg→Trp) and codon 399 (Arg→Gln) in 135 patients with esophageal squamous cell carcinoma (ESCC) and 152 normal controls from hospitals. Although polymorphism at codon 194 was not associated with risk for ESCC, we found that the frequency of XRCC1 399 Gln/Gln genotype in ESCC patients (14.1%) was significantly higher than that in normal controls (3.3%), and that XRCC1 399 Gln/Gln genotype was associated with an increased risk of ESCC (odds ratio (OR)=5.15, 95% confidence interval (CI): 2.42–0.93). In addition, we found that the risk for smoker increased 4.2-fold than non-smokers in the 399 Gln/Gln genotype (OR=4.20, 95% CI: 2.37–7.44). These results suggest that XRCC1 399 Gln/Gln genotype may contribute to the risk of ESCC and modify risk associated with smoking.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
DNA Repair
Esophageal Neoplasms
DNA repair
Biology
Bioinformatics
Gastroenterology
Esophageal squamous cell carcinoma
Risk Assessment
Cohort Studies
XRCC1
Age Distribution
Internal medicine
Genotype
medicine
Confidence Intervals
Odds Ratio
Humans
Genetic Predisposition to Disease
Sex Distribution
Aged
Neoplasm Staging
Probability
Chi-Square Distribution
Polymorphism, Genetic
Incidence
Smoking
Odds ratio
Esophageal cancer
Middle Aged
medicine.disease
Prognosis
Survival Analysis
Confidence interval
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
Increased risk
Oncology
Case-Control Studies
Carcinoma, Squamous Cell
Female
Subjects
Details
- ISSN :
- 0361090X
- Volume :
- 28
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cancer detection and prevention
- Accession number :
- edsair.doi.dedup.....d9d6bebe69762e0520f637fb020a5b37