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Clinical course and outcome of patients with COVID-19 in Mumbai City: an observational study

Authors :
Rajesh Dikshit
Rosemarie de Souza
Burhanuddin Qayyumi
D S Asgaonkar
Prem Lakhani
Tushar Madke
Pankaj Chaturvedi
Rajendra A. Badwe
Sharayu Mhatre
Ramesh N Bharmal
Mohan C. Joshi
Garvit Chitkara
Sudeep Gupta
Source :
BMJ Open, Vol 11, Iss 5 (2021), BMJ Open
Publication Year :
2021
Publisher :
BMJ Publishing Group, 2021.

Abstract

ObjectiveTo understand the outcome of hospitalised patients from Mumbai City, which had the highest number of COVID-19 cases in India.DesignObservational study with follow-up.SettingData extraction from medical records of patients with COVID-19 admitted to Nair Hospital & TN Medical College, Mumbai, India.Participants689 patients with COVID-19 were admitted in the hospital from 26 March 2020 to 11 May 2020.Primary and secondary outcome measuresIn-hospital mortality; joint effect of comorbidity and age on the risk of dying.ResultsA total of 689 patients (median age 44 years) admitted with RT-PCR-confirmed COVID-19 were included in the study. Of these, 77.36% of patients were discharged alive while 22.64% died. 11.61% required some kind of oxygen support while 2.8% of patients required intensive care unit admissions. Older age (HR 2.88, 95% CI 2.09 to 3.98), presence of comorbidities (HR 2.56, 95% CI 1.84 to 3.55), history of hypertension (HR 3.19, 95% CI 1.67 to 6.08), and presence of symptoms at the time of admission (HR 3.21, 95% CI 1.41 to 7.26) were associated with increased risk of in-hospital mortality. Treatment with a combination of azithromycin with hydroxychloroquine, antiviral or steroid compared with no treatment did not alter the disease course and in-hospital mortality. The combined effect of old age and presence of comorbid conditions was more pronounced in women than men.ConclusionsIn-hospital patients were younger, less symptomatic with lesser need of ventilators and oxygen support as compared with many western countries.Trial registrationNot applicable (observational study, not a clinical trial).

Details

Language :
English
ISSN :
20446055
Volume :
11
Issue :
5
Database :
OpenAIRE
Journal :
BMJ Open
Accession number :
edsair.doi.dedup.....d9d08c5d1a3f4dca630db8c2003dc5b4