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Activated Protein C Does Not Alleviate the Course of Systemic Inflammation in the APCAP Trial
- Source :
- International Journal of Inflammation, Vol 2012 (2012), International Journal of Inflammation
- Publication Year :
- 2012
- Publisher :
- Hindawi Limited, 2012.
-
Abstract
- The study aimed to determine the effect of the activated protein C on the course of systemic inflammation in the APCAP (activated protein C in acute pancreatitis) trial where we randomized 32 patients with severe acute pancreatitis to receive either recombinant activated protein C (drotrecogin alfa activated) (n=16) or placebo (n=16) for 96 hours. In the present study, we present the time course of the patients’ plasma or serum levels of soluble markers (IL-8, IL-6, IL-10, IL-1ra, sE-selectin, PCT) and monocyte and neutrophil cell surface (CD11b, CD14, CD62L, HLA-DR) markers of systemic inflammatory response during the first 14 days after the randomization. The results of the intervention and placebo groups were comparable showing that recombinant APC treatment did not alter the course of systemic inflammation in severe acute pancreatitis. Our finding is in accordance with the clinical findings in the APCAP trial indicating that the intervention did not affect evolution of multiple organ dysfunctions.
- Subjects :
- medicine.medical_specialty
Pathology
Randomization
Article Subject
CD14
Systemic inflammation
Placebo
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
lcsh:Pathology
medicine
Immunology and Allergy
business.industry
Monocyte
Drotrecogin alfa
medicine.disease
3. Good health
medicine.anatomical_structure
030220 oncology & carcinogenesis
Acute pancreatitis
030211 gastroenterology & hepatology
medicine.symptom
business
Protein C
Research Article
lcsh:RB1-214
medicine.drug
Subjects
Details
- ISSN :
- 20420099 and 20908040
- Volume :
- 2012
- Database :
- OpenAIRE
- Journal :
- International Journal of Inflammation
- Accession number :
- edsair.doi.dedup.....d9b3f4b08d4545078be2293e642f09f6