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Early-Life Risk Factors for Breast Cancer – Prospective Follow-up in the Northern Finland Birth Cohort 1966
- Source :
- Cancer Epidemiology, Biomarkers & Prevention. 30:616-622
- Publication Year :
- 2021
- Publisher :
- American Association for Cancer Research (AACR), 2021.
-
Abstract
- Background: While some risk factors for breast cancer have been confirmed, less is known about the role of early biological and social risk factors for breast cancer in adult life. Methods: In a prospective follow-up in the Northern Finland Birth Cohort 1966 consisting of 5,308 women, 120 breast cancers were reported via national registers by the end of 2018. Early risk factors were examined with univariate and multivariate analyses using Cox regression analysis. The main results are reported with HRs and their 95% confidence intervals (CI). Results: In the multivariate-adjusted models, women whose mothers lived in urban areas (HR, 1.68; 95% CI, 1.13–2.51) during pregnancy, were low educated (HR, 2.40; 95% CI, 1.30–4.45), and had been diagnosed with breast cancer (HR, 1.97; 95% CI, 1.09–3.58) had a higher risk for breast cancer in adult life. Lower BMI at the age of 14 associated nonsignificantly with the risk of breast cancer (Mann–Whitney U test, P = 0.087). No association between birth size and breast cancer risk in adult life was found. Conclusions: Early-life residence and socioeconomic conditions may have an impact on developing breast cancer in women in adult life. All breast cancer cases of this study were relatively young, and most of them are assumed to be premenopausal. Impact: This study is one of a few prospective birth cohort studies to examine early-life socioeconomic factors and breast cancer risk in adult life. This study is limited due to small number of cases.
- Subjects :
- Adult
0301 basic medicine
medicine.medical_specialty
Multivariate analysis
Urban Population
Epidemiology
Population
Breast Neoplasms
03 medical and health sciences
0302 clinical medicine
Breast cancer
Risk Factors
Humans
Medicine
Prospective Studies
Registries
education
Finland
Pregnancy
education.field_of_study
business.industry
Obstetrics
Proportional hazards model
Hazard ratio
Middle Aged
medicine.disease
3. Good health
030104 developmental biology
Socioeconomic Factors
Oncology
Risk factors for breast cancer
030220 oncology & carcinogenesis
Menarche
Educational Status
Birth Cohort
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15387755 and 10559965
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Cancer Epidemiology, Biomarkers & Prevention
- Accession number :
- edsair.doi.dedup.....d9b0dcd57f78230b39db6108d479e0ba