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Multiline treatment of advanced squamous cell carcinoma of the lung: A case report and review of the literature

Authors :
Xin Yang
Li Zhang
Ping Peng
Source :
World Journal of Clinical Cases
Publication Year :
2019
Publisher :
Baishideng Publishing Group Inc, 2019.

Abstract

BACKGROUND Squamous cell carcinoma (SCC) is one the most common subtypes of non-small cell lung cancer, yet the treatment options for it remain limited. Here, we report a case of advanced SCC and review the related literature focusing on the multiline therapy method. CASE SUMMARY We report the case of a 45-year-old man with advanced SCC who was deemed inoperable at the time of advanced SCC diagnosis. The patient had been referred to our hospital in April 2013 with complaints of a stuffy feeling in the chest, dyspnea, and pain in the right shoulder lasting for 1 mo. Physical examination found no obvious abnormalities, except for lower breath sound in the right lower lung. Laboratory data were within normal limits. Immunohistochemistry analysis of the tumor tissue showed CK5/6 (+), p63 (+), CD56 (+), and Ki-67 (+, approximately 30%), and genetic testing detected no EGFR mutation. He received a multiline treatment that included chemotherapy, radiotherapy, targeted therapy, and antiangiogenic therapy. After more than 5-year comprehensive treatment, the patient remains alive. CONCLUSION This typical case highlights the importance of appropriate multiline therapy for those patients with advanced SCC.

Details

Language :
English
ISSN :
23078960
Volume :
7
Issue :
14
Database :
OpenAIRE
Journal :
World Journal of Clinical Cases
Accession number :
edsair.doi.dedup.....d99e0e2bc7e663190f43b24964886b78