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Clinical Characteristics and Changes of Clinical Features in Patients with Asthma-COPD Overlap in Korea according to Different Diagnostic Criteria
- Source :
- Tuberculosis and Respiratory Diseases, Vol 83, Iss Supple 1, Pp S34-S45 (2020), Tuberculosis and Respiratory Diseases
- Publication Year :
- 2020
- Publisher :
- The Korean Academy of Tuberculosis and Respiratory Diseases, 2020.
-
Abstract
- Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a condition characterized by the overlapping clinical features of asthma and COPD. To evaluate the appropriateness of different sets of ACO definition, we compared the clinical characteristics of the previously defined diagnostic criteria and the specialist opinion in this study. Methods: Patients enrolled in the KOrea COpd Subgroup Study (KOCOSS) were evaluated. Based on the questionnaire data, the patients were categorized into the ACO and non-ACO COPD groups according to the four sets of the diagnostic criteria. Results: In total 1,475 patients evaluated: 202 of 1,475 (13.6%), 32 of 1,475 (2.2%), 178 of 1,113 (16.0%), and 305 of 1,250 (24.4%) were categorized as ACO according to the modified Spanish Society of Pneumonology and Thoracic Surgery (SEPAR), American Thoracic Society (ATS) Roundtable, Global Initiative for Asthma (GINA)/Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, and the specialists diagnosis, respectively. The ACO group defined according to the GINA/GOLD criteria showed significantly higher St. George''s Respiratory Questionnaire and COPD Assessment Test scores than the non-ACO COPD group. When the modified SEPAR definition was applied, the ACO group showed a significantly larger decrease in the forced expiratory volume in 1 second (FEV1, %). The ACO group defined by the ATS Roundtable showed significantly larger decrease in the forced vital capacity values compared to the non-ACO COPD group (-18.9% vs. -2.2%, p=0.007 and -412 mL vs. -17 mL, p=0.036). The ACO group diagnosed by the specialists showed a significantly larger decrease in the FEV1 (%) compared to the non-ACO group (-5.4% vs. -0.2%, p=0.003). Conclusion: In this study, the prevalence and clinical characteristics of ACO varied depending on the diagnostic criteria applied. With the criteria which are relatively easy to use, defining ACO by the specialists diagnosis may be more practical in clinical applications.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Vital capacity
Pulmonary function testing
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
COPD
In patient
030212 general & internal medicine
Asthma copd overlap
Asthma
lcsh:RC705-779
business.industry
pulmonary function
lcsh:Diseases of the respiratory system
asthma
medicine.disease
Obstructive lung disease
Infectious Diseases
030228 respiratory system
Cardiothoracic surgery
Original Article
business
chronic obstructive lung disease
Subjects
Details
- Language :
- English
- ISSN :
- 20056184 and 17383536
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Tuberculosis and Respiratory Diseases
- Accession number :
- edsair.doi.dedup.....d9979f6ac346742e12315d2451255d16