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Association between Serum 25-Hydroxyvitamin D Level and Cognitive Impairment in Patients with White Matter Lesions: A Cross-Sectional Study
- Source :
- Med Princ Pract
- Publication Year :
- 2020
- Publisher :
- S. Karger AG, 2020.
-
Abstract
- Objectives: We aimed to observe the relationship between serum 25-hydroxyvitamin D (25-[OH] D) and different cognitive domains, and to evaluate the predictive value of 25-(OH) D level for cognitive impairment in patients with white matter lesions (WML). Methods: The differences in clinical data including 25-(OH) D were analyzed between cognitive normality (n = 87) and impairment (n = 139) groups, and variant cognitive domains were analyzed between groups of different levels of serum 25-(OH) D. Risk factors for cognitive impairments were evaluated with multivariate logistic regression analysis; a receiver operating characteristic (ROC) curve of 25-(OH) D levels was used to examine the association between 25-(OH) D and WML with cognitive dysfunction. Results: As the severity of WML increased, the proportion of patients with a low level of serum 25-(OH) D increased (p < 0.05). The total MoCA (Montreal Cognitive Assessment) scores and all domain scores except naming were significantly lower in patients with low levels of serum 25-(OH) D than in patients with high levels of serum 25-(OH) D (p < 0.05). Multivariate logistic regression analyses showed that serum 25-(OH) D levels were independently correlated with cognitive impairment. In the ROC analysis, the optimal cut-off value for 25-(OH) D was 17.53 with 76% sensitivity and 70% specificity (AUC =0.751, 95% CI: 0.674–0.819, p < 0.05). Conclusion: We observed that vitamin D deficiency is associated with multiple areas of cognitive impairment and that it is an independent risk factor for cognitive impairment in WML.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
020205 medical informatics
Cross-sectional study
02 engineering and technology
Logistic regression
Severity of Illness Index
Gastroenterology
vitamin D deficiency
03 medical and health sciences
Leukoencephalopathies
Risk Factors
Internal medicine
0202 electrical engineering, electronic engineering, information engineering
Humans
Medicine
Cognitive Dysfunction
Vitamin D
Risk factor
Aged
Original Paper
Receiver operating characteristic
business.industry
Montreal Cognitive Assessment
Cognition
General Medicine
Middle Aged
Mental Status and Dementia Tests
Vitamin D Deficiency
medicine.disease
White Matter
Hyperintensity
Cross-Sectional Studies
Logistic Models
ROC Curve
Female
030101 anatomy & morphology
business
Subjects
Details
- ISSN :
- 14230151 and 10117571
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Medical Principles and Practice
- Accession number :
- edsair.doi.dedup.....d9922ec6adc1375065d4b057f70cd683