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Long-range Effect of Bromine in the Deprotonative Metalation of Aromatic Compounds
- Source :
- CHIMIA, Vol 70, Iss 1-2 (2016), CHIMIA, CHIMIA, Schweizerische Chemische Gesellschaft, 2016, The French Connection, 70 (1/2), pp.48-52. ⟨10.2533/chimia.2016.48⟩, CHIMIA, 2016, The French Connection, 70 (1/2), pp.48-52. ⟨10.2533/chimia.2016.48⟩
- Publication Year :
- 2016
- Publisher :
- Swiss Chemical Society, 2016.
-
Abstract
- Deprotonative metalation has been largely used to functionalize aromatic compounds. The efficiency of such reactions, as well as their regioselectivity, depends on the substituents connected to the rings. In contrast with other groups such as fluorine and methoxy, bromine exhibits a long-range acidifying effect. Here we try to depict this particular effect of bromine through different examples in which deprotometalation takes place at a remote position.
- Subjects :
- Aromatic compounds
Bromine
Deprotonative metalation
010405 organic chemistry
Metalation
Acidity
Long-range effects
chemistry.chemical_element
Regioselectivity
General Medicine
General Chemistry
010402 general chemistry
01 natural sciences
Medicinal chemistry
0104 chemical sciences
3. Good health
Chemistry
chemistry
Fluorine
Range effect
Substituent effects
[CHIM]Chemical Sciences
QD1-999
Subjects
Details
- Language :
- German
- ISSN :
- 26732424 and 00094293
- Volume :
- 70
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- CHIMIA
- Accession number :
- edsair.doi.dedup.....d989247d112d441f3ac84d04446d663b
- Full Text :
- https://doi.org/10.2533/chimia.2016.48⟩