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On the Relative Role of Different Age Groups During Epidemics Associated With Respiratory Syncytial Virus
- Source :
- The Journal of infectious diseases. 217(2)
- Publication Year :
- 2017
-
Abstract
- Background While circulation of respiratory syncytial virus (RSV) results in high rates of hospitalization, particularly among young children and elderly individuals, little is known about the role of different age groups in propagating annual RSV epidemics. Methods We evaluate the roles played by individuals in different age groups during RSV epidemics in the United States between 2001 and 2012, using the previously defined relative risk (RR) statistic estimated from the hospitalization data from the Healthcare Cost and Utilization Project. Transmission modeling was used to examine the robustness of our inference method. Results Children aged 3-4 years and 5-6 years each had the highest RR estimate for 5 of 11 seasons included in this study, with RSV hospitalization rates in infants being generally higher during seasons when children aged 5-6 years had the highest RR estimate. Children aged 2 years had the highest RR estimate during one season. RR estimates in infants and individuals aged ≥11 years were mostly lower than in children aged 1-10 years. Highest RR values aligned with groups for which vaccination had the largest impact on epidemic dynamics in most model simulations. Conclusions Our estimates suggest the prominent relative roles of children aged ≤10 years (particularly among those aged 3-6 years) in propagating RSV epidemics. These results, combined with further modeling work, should help inform RSV vaccination policies.
- Subjects :
- 0301 basic medicine
Adult
Male
Adolescent
Respiratory Syncytial Virus Infections
Virus
03 medical and health sciences
Young Adult
Major Articles and Brief Reports
0302 clinical medicine
Age groups
Disease Transmission, Infectious
Immunology and Allergy
Medicine
Humans
030212 general & internal medicine
Respiratory system
Healthcare Cost and Utilization Project
Child
Epidemics
Aged
High rate
Aged, 80 and over
Transmission (medicine)
business.industry
Age Factors
Infant, Newborn
Infant
Middle Aged
United States
Vaccination
030104 developmental biology
Infectious Diseases
Relative risk
Child, Preschool
Female
business
Demography
Subjects
Details
- ISSN :
- 15376613
- Volume :
- 217
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....d9889353ceda15e6ca61e3dd2df5eb36