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Langerhans cell histiocytosis in the oral and maxillofacial region: An update

Authors :
Alan Roger Santos-Silva
Patrícia Maria Fernandes
Pablo Agustin Vargas
Márcio Ajudarte Lopes
Hélder Antônio Rebelo Pontes
Adalberto Mosqueda-Taylor
Isabel Schausltz Pereira Faustino
Source :
Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral PathologyREFERENCES. 50(6)
Publication Year :
2021

Abstract

Background Langerhans cell histiocytosis (LCH) is a rare disorder characterized by abnormal proliferation and infiltration of histiocytic cells. Methods This review focused on the main aspects associated with LCH. Results LCH can involve single or multiple organs and systems, with bone and skin being the most commonly affected sites. Regarding skeletal manifestations, the jawbones are involved in about 20%-30% of all cases. Such lesions may present as unilocular or multilocular images mainly affecting the posterior mandible. Oral soft tissue lesions may also occur, with the gingiva and hard palate being the most frequently affected sites. Conclusion The diagnosis and management of LCH are challenging, requiring a multidisciplinary approach, with dentists playing a central role since oral manifestations can be the first sign of the condition.

Details

ISSN :
16000714
Volume :
50
Issue :
6
Database :
OpenAIRE
Journal :
Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral PathologyREFERENCES
Accession number :
edsair.doi.dedup.....d976c7fe59fbfc076f6bdfa9eb5ba0ca