Back to Search
Start Over
Melatonin protects against Epirubicin-induced ovarian damage
- Source :
- The Journal of Reproduction and Development
- Publication Year :
- 2020
- Publisher :
- Japanese Society of Animal Reproduction, 2020.
-
Abstract
- One major side effect of chemotherapy that young women with cancer suffer from is ovarian damage. Therefore, it is necessary to study the pathogenesis of chemotherapeutic drugs in order to develop pharmaceutical agents to preserve fertility. Epirubicin is one of the commonly used chemotherapy drugs for breast cancer patients. This research explored the side effects of epirubicin in mice. We found that epirubicin significantly reduced the body weight, the weight of the ovaries and uteri, and the pups' number, while melatonin, which is extremely resistant to oxidation, significantly reduced these damages. Moreover, co-treatment with melatonin prevented epirubicin-induced decrease in Einf2/infand progesterone, and the loss of follicles. Mechanism study showed that melatonin significantly reduced the levels of proapoptotic genes p53, Caspase3, and Caspase9 while it upregulated antiapoptotic factors Bcl-2 and Bcl2l1, and antioxidant genes superoxide dismutase 1 and catalase compared with the epirubicin group. In addition, melatonin markedly reduced reactive oxygen species (ROS) and the transcription of Caspase12 and Chop, which is vital in endoplasmic reticulum stress (ERS)-mediated apoptosis. These results indicate melatonin protects against epirubicin-induced ovarian damage by reducing ROS-induced ERS. Therefore, melatonin has a therapeutic potential for the protection of ovarian function and preservation of fertility during chemotherapy.
- Subjects :
- Antioxidant
medicine.medical_treatment
Apoptosis
Endoplasmic reticulum stress (ERS)
Pharmacology
CHOP
Protective Agents
Superoxide dismutase
Melatonin
Mice
03 medical and health sciences
0302 clinical medicine
Animals
Medicine
skin and connective tissue diseases
Progesterone
Epirubicin
030304 developmental biology
chemistry.chemical_classification
Mice, Inbred ICR
0303 health sciences
Reactive oxygen species
Chemotherapy
Antibiotics, Antineoplastic
030219 obstetrics & reproductive medicine
Estradiol
biology
Caspase 3
business.industry
Body Weight
Ovary
Uterus
Reactive oxygen species (ROS)
Endoplasmic Reticulum Stress
Caspase 9
Ovarian damage
Oxidative Stress
chemistry
biology.protein
Female
Original Article
Animal Science and Zoology
Reactive Oxygen Species
business
medicine.drug
Subjects
Details
- ISSN :
- 13484400 and 09168818
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Journal of Reproduction and Development
- Accession number :
- edsair.doi.dedup.....d97153df16cb83eca8fdd99490f9bcfd