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Optimization of the MHC Class I Peptide Cargo Is Dependent on Tapasin
- Source :
- Immunity. 16(4):509-520
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- The loading of MHC class I molecules with their peptide cargo is undertaken by a multimolecular peptide loading complex within the endoplasmic reticulum. We show that MHC class I molecules can optimize their peptide repertoire over time and that this process is dependent on tapasin. Optimization of the peptide repertoire is both quantitatively and qualitatively improved by tapasin. The extent of optimization is maximal when MHC class I molecules are allowed to load within the fully assembled peptide loading complex. Finally, we identify a single natural polymorphism (116D>Y) in HLA-B*4402 that permits tapasin-independent loading of HLA-B*4405 (116Y). In the presence of tapasin, the tapasin-independent allele B*4405 (116Y) acquires a repertoire of peptides that is less optimal than the tapasin-dependent allele B*4402 (116D).
- Subjects :
- Intracellular Fluid
Time Factors
Immunology
Immunoglobulins
Peptide
Antiporters
Catalysis
Cell Line
HLA-B44 Antigen
03 medical and health sciences
0302 clinical medicine
Tapasin
MHC class I
Humans
Immunology and Allergy
ATP Binding Cassette Transporter, Subfamily B, Member 2
HLA-B27 Antigen
030304 developmental biology
chemistry.chemical_classification
Antigen Presentation
0303 health sciences
Binding Sites
biology
Antigen processing
Endoplasmic reticulum
Repertoire
Cell Membrane
Histocompatibility Antigens Class I
Membrane Transport Proteins
Transporter associated with antigen processing
MHC restriction
Molecular biology
Cell biology
Infectious Diseases
chemistry
HLA-B Antigens
biology.protein
ATP-Binding Cassette Transporters
Peptides
Molecular Chaperones
030215 immunology
Subjects
Details
- ISSN :
- 10747613
- Volume :
- 16
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.doi.dedup.....d96794f57feb81c916e68ca2387edf8e
- Full Text :
- https://doi.org/10.1016/s1074-7613(02)00304-7