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Can rebamipide and proton pump inhibitor combination therapy promote the healing of endoscopic submucosal dissection–induced ulcers? A randomized, prospective, multicenter study
- Source :
- Gastrointestinal Endoscopy. 75:739-747
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Background There has been no consensus regarding the optimal treatment durations and drug regimens in patients with endoscopic submucosal dissection (ESD)–induced ulcers. Objective To assess the efficacy of proton pump inhibitor (PPI) and rebamipide combination therapy compared with PPI monotherapy for ESD-induced ulcer healing. Design Randomized, prospective, controlled study; clinical trial. Setting Five hospitals in a University Medical Center group in Korea. Patients This study involved 290 adults (309 lesions) who underwent ESD for gastric adenoma or early gastric cancer. Intervention PPI and rebamipide combination therapy. Main Outcome Measurements The ulcer healing rate at 4 weeks after ESD. Results The ulcer healing rates at 4 weeks after ESD in the PPI and rebamipide combination therapy group were significantly higher than those in the PPI alone group, both in the full analysis (94.9% vs 89.9%; P P = .020). This combination therapy was an independent predictive factor for a high ulcer healing rate (adjusted odds ratio [OR] 5.572; 95% confidence interval [CI], 2.615-11.876; P = .014). Additionally, the combination therapy group exhibited a higher quality of ulcer healing than the PPI monotherapy group (reviewer 1: P = .027; OR 1.949; 95% CI, 1.077-3.527; reviewer 2: P = .027; OR 1.933; 95% CI, 1.074-3.481). Limitations Open-label study. Conclusion PPI and rebamipide combination therapy had a superior 4-week ESD-induced ulcer healing rate and quality of ulcer healing compared with PPI monotherapy. (Clinical trial registration number: NCT01167101.)
- Subjects :
- Adenoma
Male
medicine.medical_specialty
Combination therapy
medicine.drug_class
Proton-pump inhibitor
Quinolones
Gastroenterology
law.invention
Pharmacotherapy
Randomized controlled trial
Stomach Neoplasms
law
Internal medicine
Gastroscopy
Confidence Intervals
Odds Ratio
medicine
Humans
Radiology, Nuclear Medicine and imaging
Stomach Ulcer
Aged
Alanine
Chi-Square Distribution
business.industry
Dissection
Carcinoma
Proton Pump Inhibitors
Odds ratio
Middle Aged
Anti-Ulcer Agents
Clinical trial
Gastric Mucosa
Rebamipide
Drug Therapy, Combination
Female
business
Chi-squared distribution
medicine.drug
Subjects
Details
- ISSN :
- 00165107
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Gastrointestinal Endoscopy
- Accession number :
- edsair.doi.dedup.....d965f0dbec25642751f93a06f8db45a3