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Long-term Survival in Korean Elderly Patients with Symptomatic Severe Aortic Stenosis Who Refused Aortic Valve Replacement
- Source :
- Korean Circulation Journal
- Publication Year :
- 2019
- Publisher :
- The Korean Society of Cardiology, 2019.
-
Abstract
- Background and Objectives Aortic valve replacement (AVR) is the treatment of choice in severe symptomatic aortic stenosis (AS) patients. However, a substantial number of elderly patients refuse AVR and treated medically. We investigated their long-term prognosis. Methods From January 2005 to December 2016, we analyzed elderly patients with severe symptomatic AS who refused to have AVR. Results After screening of total 534 patients, we analyzed total 180 severe symptomatic AS patients (78±7 years old, 96 males). Hypertension was the most common cardiovascular risk factor (72%) and the most common symptom was dyspnea (66%). Calculated aortic stenosis area was 0.73±0.20 cm2 and mean left ventricular ejection fraction (LVEF) was 57.8±12.2%. Total 102 patients died during follow-up period (39.1±31.0 months). One-, 3-, and 5-year all-cause mortality rate was 21.1±3.0%, 43.1±3.8%, and 56.5±4.2%, respectively. Of them, 87 died from cardiac causes, and 1-, 3-, and 5-year cardiac mortality rate was 18.0±2.9%, 38.2±3.8%, and 50.7±4.3%, respectively. Their all-cause mortality and cardiac mortality were significantly higher than those of controls. Univariate analysis showed that age, anemia, LVEF, and Log N-terminal pro B-type natriuretic peptide (NT-proBNP) were significant parameters in all-cause mortality (p
- Subjects :
- medicine.medical_specialty
Survival
Anemia
Aortic valve stenosis
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Aortic valve replacement
Internal medicine
Internal Medicine
medicine
030212 general & internal medicine
Risk factor
Univariate analysis
Ejection fraction
business.industry
Mortality rate
Prognosis
medicine.disease
Stenosis
Cardiology
Original Article
Drug therapy
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 17385555 and 17385520
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Korean Circulation Journal
- Accession number :
- edsair.doi.dedup.....d95c67d2a492d9bd16849fe1cdaa31d9