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Viral clearance after early corticosteroid treatment in patients with moderate or severe covid-19
- Source :
- Scientific Reports, Scientific reports, 10:21291
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The aim of this study was to evaluate the impact of early treatment with corticosteroids on SARS-CoV-2 clearance in hospitalized COVID-19 patients. Retrospective analysis on patients admitted to the San Raffaele Hospital (Milan, Italy) with moderate/severe COVID-19 and availability of at least two nasopharyngeal swabs. The primary outcome was the time to nasopharyngeal swab negativization. A multivariable Cox model was fitted to determine factors associated with nasopharyngeal swab negativization. Of 280 patients included, 59 (21.1%) patients were treated with steroids. Differences observed between steroid users and non-users included the proportion of patients with a baseline PaO2/FiO2 ≤ 200 mmHg (45.8% vs 34.4% in steroids and non-steroids users, respectively; p = 0.023) or ≤ 100 mmHg (16.9% vs 12.7%; p = 0.027), and length of hospitalization (20 vs 14 days; p 2/FiO2 > 200 mmHg, and a lymphocyte count at admission > 1.0 × 109/L. SARS-CoV-2 clearance was not associated with corticosteroid use. Our study shows that delayed SARS-CoV-2 clearance in moderate/severe COVID-19 is associated with older age and a more severe disease, but not with an early use of corticosteroids.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Coronavirus disease 2019 (COVID-19)
Lymphocyte
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Corticosteroid treatment
Severe disease
Diseases
030204 cardiovascular system & hematology
Article
03 medical and health sciences
0302 clinical medicine
Adrenal Cortex Hormones
Internal medicine
medicine
Humans
In patient
030212 general & internal medicine
Pandemics
Aged
Retrospective Studies
Multidisciplinary
business.industry
Proportional hazards model
Age Factors
COVID-19
Retrospective cohort study
Middle Aged
Viral Load
Publisher Correction
COVID-19 Drug Treatment
Hospitalization
Treatment Outcome
Infectious diseases
Viral infection
medicine.anatomical_structure
Italy
Female
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....d951b3d0853f9523240c917fea3e1f61