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Antitumor activity of Tigerinin-1: Necroptosis mediates toxicity in A549 cells
- Source :
- Biochimica et biophysica acta. General subjects. 1866(9)
- Publication Year :
- 2022
-
Abstract
- Tigerinins are antimicrobial peptides (AMPs) derived from the skin secretions of the Indian bullfrog Hoplobatrachus tigerinus.Tigerinin-1 (FCTMIPIPRCY-Am) peptide was synthesized by solid-phase Fmoc chemistry and investigated its antitumor activities.Tigerinin-1 was cytotoxic to human cancer cells. It causes necrosis by damaging the cell membrane and loss of lysosome integrity. Tigerinin-1triggers the expression of necroptosis pathway proteins. It generates reactive oxygen species (ROS) and induces oxidative stress-mediated genotoxicity. Tigerinin-1 inhibits cancer cell proliferation, reduces neovascularization, and down-regulates the vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor 2 (VEGFR2), and fibroblast growth factor (FGF) genes.Tigerinin-1 exhibited its potent antitumor properties in this study.Tigerinin-1 can be beneficial for developing novel therapeutics for cancer.
Details
- ISSN :
- 18728006
- Volume :
- 1866
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Biochimica et biophysica acta. General subjects
- Accession number :
- edsair.doi.dedup.....d950f54203839ab002ac512d0caa12ee