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Evidence-based guideline: Treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation
- Source :
- Neurology. 76(20)
- Publication Year :
- 2011
-
Abstract
- Objective: To develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN). Methods: We performed a systematic review of the literature from 1960 to August 2008 and classified the studies according to the American Academy of Neurology classification of evidence scheme for a therapeutic article, and recommendations were linked to the strength of the evidence. The basic question asked was: “What is the efficacy of a given treatment (pharmacologic: anticonvulsants, antidepressants, opioids, others; and nonpharmacologic: electrical stimulation, magnetic field treatment, low-intensity laser treatment, Reiki massage, others) to reduce pain and improve physical function and quality of life (QOL) in patients with PDN?” Results and Recommendations: Pregabalin is established as effective and should be offered for relief of PDN (Level A). Venlafaxine, duloxetine, amitriptyline, gabapentin, valproate, opioids (morphine sulfate, tramadol, and oxycodone controlled-release), and capsaicin are probably effective and should be considered for treatment of PDN (Level B). Other treatments have less robust evidence or the evidence is negative. Effective treatments for PDN are available, but many have side effects that limit their usefulness, and few studies have sufficient information on treatment effects on function and QOL. Neurology ® 2011;76:1–1
- Subjects :
- medicine.medical_specialty
Neurology
Gabapentin
Pregabalin
Pain
Electric Stimulation Therapy
chemistry.chemical_compound
Physical medicine and rehabilitation
Electromagnetic Fields
Diabetic Neuropathies
Medicine
Duloxetine
Humans
Pain Management
Massage
Evidence-Based Medicine
business.industry
Evidence-based medicine
Guideline
Antidepressive Agents
Analgesics, Opioid
chemistry
Physical therapy
Anticonvulsants
Neurology (clinical)
business
Oxycodone
medicine.drug
Subjects
Details
- ISSN :
- 1526632X
- Volume :
- 76
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....d943d2eb9cbd2ac88cecfbb173d121ed