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The geldanamycin derivative 17-AAG decreases VEGF secretion and leukemia growth support by trisomy 8 myelodysplastic syndrome bone marrow stromal cells
- Source :
- Pediatric hematology and oncology. 22(2)
- Publication Year :
- 2005
-
Abstract
- Stromal cells from a child with constitutional trisomy 8 who developed myelodysplastic syndrome (MDS) were found to produce abnormal levels of various cytokines, including VEGF, and supported the growth of leukemic cells in co-culture assays. This study shows that the geldanamycin derivative 17-AAG effectively reduces the VEGF expression by MDS stromal cells. In co-culture experiments this agent also blocks the ability of the MDS stromal cells to stimulate the growth of leukemic cells. These data provide important initial evidence for the effect of 17-AAG on the marrow microenvironment and its potential use in the treatment of MDS and leukemia.
- Subjects :
- Vascular Endothelial Growth Factor A
Stromal cell
VEGF receptors
Lactams, Macrocyclic
Vegf expression
Bone Marrow Cells
Trisomy
Trisomy 8
chemistry.chemical_compound
hemic and lymphatic diseases
Paracrine Communication
polycyclic compounds
medicine
Benzoquinones
Tumor Cells, Cultured
Humans
Secretion
Child
Cell Proliferation
Leukemia
biology
business.industry
Hematology
Geldanamycin
medicine.disease
Coculture Techniques
medicine.anatomical_structure
Oncology
chemistry
Rifabutin
Myelodysplastic Syndromes
Pediatrics, Perinatology and Child Health
Immunology
Cancer research
biology.protein
Cytokines
Female
Bone marrow
Stromal Cells
business
Chromosomes, Human, Pair 8
Subjects
Details
- ISSN :
- 08880018
- Volume :
- 22
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Pediatric hematology and oncology
- Accession number :
- edsair.doi.dedup.....d93e8d265e2d2cd770a18622ec33f599