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Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection
- Source :
- PLoS ONE, PLoS ONE, Vol 16, Iss 11, p e0259902 (2021), PLoS ONE, Vol 16, Iss 11 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science, 2021.
-
Abstract
- Background Coronavirus disease 2019 (COVID-19) is associated with endothelial activation and coagulopathy, which may be related to pre-existing or infection-induced pro-thrombotic autoantibodies such as those targeting angiotensin II type I receptor (AT1R-Ab). Methods We compared prevalence and levels of AT1R-Ab in COVID-19 cases with mild or severe disease to age and sex matched negative controls utilizing multivariate logistic and quantile regression adjusted for comorbidities including hypertension, diabetes, and heart disease. Results There were trends toward increased prevalence (50% vs. 33%, p = 0.1) and level of AT1R-Ab (median 9.8 vs. 6.1 U/mL, p = 0.06) in all cases versus controls. When considered by COVID-19 disease severity, there was a trend toward increased prevalence of AT1R-Ab (55% vs. 31%, p = 0.07), as well as significantly higher AT1R-Ab levels (median 10.7 vs. 5.9 U/mL, p = 0.03) amongst individuals with mild COVID-19 versus matched controls. In contrast, the prevalence (42% vs. 37%, p = 0.9) and level (both medians 6.7 U/mL, p = 0.9) of AT1R-Ab amongst those with severe COVID-19 did not differ from matched controls. Conclusions These findings support an association between COVID-19 and AT1R-Ab, emphasizing that vascular pathology may be present in individuals with mild COVID-19 as well as those with severe disease.
- Subjects :
- RNA viruses
Graft Rejection
Male
Angiotensin receptor
Viral Diseases
Heart disease
Pulmonology
Coronaviruses
Physiology
Cardiovascular Medicine
Gastroenterology
Vascular Medicine
Biochemistry
Medical Conditions
Coagulopathy
Immune Physiology
Medicine and Health Sciences
Enzyme-Linked Immunoassays
Kidney transplantation
Pathology and laboratory medicine
Innate Immune System
Multidisciplinary
Immune System Proteins
Hematology
Medical microbiology
Middle Aged
Infectious Diseases
Cardiovascular Diseases
Viruses
Medicine
Cytokines
SARS CoV 2
Pathogens
Research Article
Adult
medicine.medical_specialty
SARS coronavirus
Science
Immunology
Cardiology
Research and Analysis Methods
Microbiology
Antibodies
Receptor, Angiotensin, Type 1
Endothelial activation
Respiratory Disorders
Internal medicine
Diabetes mellitus
medicine
Humans
Immunoassays
Blood Coagulation
Biology and life sciences
Coagulation Disorders
business.industry
Autoantibody
Organisms
Viral pathogens
Proteins
COVID-19
Covid 19
Thrombosis
Molecular Development
medicine.disease
Angiotensin II
Kidney Transplantation
Microbial pathogens
Immune System
Respiratory Infections
Immunologic Techniques
business
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....d93c572895435fe1f6d983798f6e18eb