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A Report of Four Cases of Blackwater Fever after Quinine Treatment at Zinder National Hospital, Niger Republic

Authors :
Doutchi Mahamadou
Ibrahim Maman Laminou
Garba Abdoul-Aziz
Adehossi Eric
Iliassou Aboubacar
Adamou Harissou
Moussa Tondi Maiga Zeinabou
Ali Osseini
Alkassoum Ibrahim
Diongolé M. Hassane
Source :
Case Reports in Infectious Diseases, Vol 2019 (2019), Case Reports in Infectious Diseases
Publication Year :
2019
Publisher :
Hindawi Limited, 2019.

Abstract

Background. Blackwater fever (BWF) is a rare but serious complication of malaria that is a consequence of antimalarial treatment. Its prevalence seems to have increased. Its diagnosis is based on clinical symptoms and urine color. We report on 4 BWF cases admitted to the infectious diseases department of Zinder National Hospital. Results. Four patients were hospitalized in September 2017 for a hepatorenal syndrome of jaundice, port wine-colored urine, renal failure, and hepatic cytolysis following antimalarial treatment with quinine salts. Quinine treatment was stopped and treatment was continued with injectable artemether. Three patients underwent extra-renal purification. Their evolution was favorable. One patient died less than 24 hours after admission. Conclusion. A rare and severe complication, blackwater fever must be considered for patients under antimalarial treatment who present with jaundice, abdominal pain, and acute renal insufficiency with port wine-colored urine. Rapid diagnosis and management in an intensive care unit are crucial for improving the prognosis.

Details

ISSN :
20906633 and 20906625
Volume :
2019
Database :
OpenAIRE
Journal :
Case Reports in Infectious Diseases
Accession number :
edsair.doi.dedup.....d92e08759ecd2bc4d53d406ac0990179