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Clear cell sarcoma expressing a novel chimerical transcript EWSR1 exon 7/ATF1 exon 6
- Source :
- Virchows Archiv. 461:339-343
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Clear cell sarcoma harbours recurrent translocation, resulting in EWSR1/ATF1 or less commonly EWSR1/CREB1 fusion. To date, six types of EWSR1/ATF1 fusion have been reported, of which three are in-frame and encode functional proteins. We present a reverse transcription - polymerase chain reaction analysis of a tumour near the hallux of the right foot. The sequencing of obtained fragments revealed the presence of a novel chimerical transcript-the in-frame fusion between EWSR1 exon 7 and ATF1 exon 6 that represents the fourth in-frame type of EWSR1/ATF1 fusion identified in clear cell sarcomas.
- Subjects :
- Adult
Male
Oncogene Proteins, Fusion
Bone Neoplasms
Soft Tissue Neoplasms
Chromosomal translocation
Biology
Translocation, Genetic
Pathology and Forensic Medicine
Exon
Fatal Outcome
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Molecular Biology
ATF1
Reverse Transcriptase Polymerase Chain Reaction
Polymerase chain reaction analysis
Exons
Cell Biology
General Medicine
medicine.disease
Molecular biology
Reverse transcriptase
Lymphatic Metastasis
Cancer research
biology.protein
Hallux
Sarcoma, Clear Cell
Clear-cell sarcoma
CREB1
Clear cell
Subjects
Details
- ISSN :
- 14322307 and 09456317
- Volume :
- 461
- Database :
- OpenAIRE
- Journal :
- Virchows Archiv
- Accession number :
- edsair.doi.dedup.....d9195276fe269255da6ce4120107d495