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A phase I pilot study evaluating the beneficial effects of black raspberries in patients with Barrett’s esophagus
- Source :
- Oncotarget
- Publication Year :
- 2016
- Publisher :
- Impact Journals LLC, 2016.
-
Abstract
- // Laura A. Kresty 1 , John J. Fromkes 2 , Wendy L. Frankel 3 , Cynthia D. Hammond 2 , Navindra P. Seeram 4 , Maureen Baird 3 , Gary D. Stoner 1 1 Division of Hematology & Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA 2 Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA 3 Department of Pathology, The Ohio State University, Columbus, Ohio, USA 4 Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA Correspondence to: Laura A. Kresty, email: Lkresty@mcw.edu Keywords: Barrett’s esophagus, black raspberry, esophageal adenocarcinoma, chemoprevention, oxidative stress Received: February 18, 2016 Accepted: May 23, 2016 Published: July 7, 2016 ABSTRACT Black raspberries inhibit a broad range of cancers in preclinical models which has led to clinical evaluations targeting premalignant lesions of the colon, oral cavity and esophagus. A phase I pilot study was conducted in twenty Barrett’s esophagus (BE) patients to investigate the effect of lyophilized black raspberries (LBR) on urinary metabolites and markers of lipid peroxidation, DNA damage and tissue markers of cellular proliferation, detoxification, and inflammation. Surveys, biopsies, blood and urine samples were collected before and after 6 months of LBR treatment (32 or 45 g). LBR significantly reduced urinary excretion of 8-epi-prostaglandin F2α, a marker of lipid peroxidation linked to oxidative stress and free radical damage. Urinary levels of the ellagitannin metabolites, urolithin A-glucuronide, urolithin A-sulfate and dimethylellagic acid glucuronide were significantly increased following 12 and 26 weeks of LBR consumption and may prove useful as indicators of compliance in future clinical studies. Immunohistochemical staining of BE biopsies following LBR treatment showed significant increases in mean GST-pi levels, with 55.6% of subjects responding favorably. In summary, LBR significantly decreased urinary lipid peroxidation levels and significantly increased GST-pi, a marker of detoxification, in BE epithelium. Still, LBR may need to be formulated differently, administered at higher concentrations or multiple times a day to increase efficacy.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Pathology
esophageal adenocarcinoma
Urinary system
black raspberry
Urine
Gastroenterology
Lipid peroxidation
03 medical and health sciences
chemistry.chemical_compound
Barrett's esophagus
0302 clinical medicine
Black raspberry
Internal medicine
medicine
chemoprevention
oxidative stress
Esophagus
Hematology
biology
business.industry
medicine.disease
biology.organism_classification
Urolithin
030104 developmental biology
medicine.anatomical_structure
Oncology
chemistry
030220 oncology & carcinogenesis
Clinical Research Paper
business
Subjects
Details
- Language :
- English
- ISSN :
- 19492553
- Volume :
- 9
- Issue :
- 82
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....d909753a2ece82086d223472c24e8653