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Anticancer Effect of Mountain Ginseng on Human Breast Cancer: Comparison with Farm-Cultivated Ginseng
- Source :
- Evidence-based Complementary and Alternative Medicine : eCAM, Evidence-Based Complementary and Alternative Medicine, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi, 2020.
-
Abstract
- Mountain ginseng has been used generally as a pharmacopuncture for cancer therapy in clinical practice in Northeast Asia. Nonetheless, there have been few scientific reports for the anticancer action of mountain ginseng. In this study, we investigated whether mountain ginseng extract (MGE) could inhibit the growth of breast cancer in in vitro and in vivo models. MGE showed stronger cytotoxicity than farm-cultivated ginseng extract (FGE) through promoting ROS generation. Also MGE dose-dependently brought about mitochondrial dysfunction in MCF-7 cells. In addition, MGE induced apoptosis through enhancing the activities of caspase-3/7 by regulation of expression of Bcl-2, Bax, cytochrome c, and cleaved caspase-3 in the MCF-7 cells. Consistent with the in vitro results, MGE significantly reduced tumor weights compared with FGE in mice transplanted with MCF-7 cells, and it regulated the expression of apoptosis-related proteins, such as Bcl-2, Bax, cytochrome c, cleaved caspase-3, and cleaved PARP, in the tumor tissues. Additionally, MGE included higher total ginsenoside contents than FGE. In conclusion, MGE, which is richer in ginsenosides, exerts a stronger anticancer action than FGE in breast cancer. The anticancer action of MGE may be closely correlated with caspase-mediated apoptosis through upregulating ROS generation. Therefore, these findings may be helpful for a clinical understanding of the anticancer mechanism of MGE for breast cancer patients.
- Subjects :
- 0303 health sciences
Article Subject
Cytochrome c
Cancer
Pharmacology
Biology
medicine.disease
In vitro
03 medical and health sciences
chemistry.chemical_compound
Ginseng
Other systems of medicine
0302 clinical medicine
Complementary and alternative medicine
chemistry
In vivo
Ginsenoside
Apoptosis
030220 oncology & carcinogenesis
biology.protein
medicine
Cytotoxicity
RZ201-999
030304 developmental biology
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 17414288 and 1741427X
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Evidence-based Complementary and Alternative Medicine : eCAM
- Accession number :
- edsair.doi.dedup.....d9045a2a574d0c6c7baf8702dd0235b8