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Association of the circulating adiponectin concentration with coronary in-stent restenosis in haemodialysis patients
- Source :
- Nephrology Dialysis Transplantation. 21:1640-1647
- Publication Year :
- 2006
- Publisher :
- Oxford University Press (OUP), 2006.
-
Abstract
- Background Success of coronary stenting is limited by in-stent restenosis. We aimed to determine whether circulating levels of the cytokines, which have anti-inflammatory properties such as adiponectin or interleukin-10, could be associated with the occurrence of coronary in-stent restenosis in patients with end-stage renal disease (ESRD). Methods We enrolled 71 consecutive ESRD patients undergoing haemodialysis (mean age: 64.9+/-8.9 years; 19 women, 52 men; mean haemodialysis duration: 78.2+/-87.5 months), who received stenting for a single coronary lesion. Plasma concentrations of adiponectin and IL-10 were measured within one week before coronary stenting. Results Of the 71 patients who had received stenting, in-stent restenosis occurred in 37 patients (52.1%) within 6 months after stenting. In univariate logistic analysis, the homeostasis model assessment index of insulin resistance, blood haemoglobin, serum concentrations of high density lipoprotein-cholesterol or triglycerides and plasma concentrations of insulin or adiponectin were significantly associated with coronary in-stent restenosis. In a multiple logistic regression analysis among these variables, however, only the plasma adiponectin concentration was associated with the coronary in-stent restenosis: the odds ratio of the increase in 1 microg/ml of plasma adiponectin concentration for having restenosis was 0.651 (P = 0.001, 95% confidence interval: 0.506-0.839). Patients with restenosis had lower plasma adiponectin concentrations than those without [6.2+/-2.2 microg/ml (2.1-10.4 microg/ml; n = 37) vs 27.2+/-10.8 microg/ml (17.9-79.8 microg/ml; n = 34); P = 0.0001]. Conclusions Circulating adiponectin concentrations may be associated with the occurrence of coronary in-stent restenosis in ESRD patients undergoing maintenance haemodialysis.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Coronary Restenosis
Coronary artery disease
Insulin resistance
Restenosis
Renal Dialysis
Internal medicine
Odds Ratio
medicine
Humans
Aged
Transplantation
Adiponectin
business.industry
Stent
Odds ratio
Middle Aged
medicine.disease
Nephrology
Cardiology
Kidney Failure, Chronic
Female
Stents
Hemodialysis
business
Kidney disease
Subjects
Details
- ISSN :
- 14602385 and 09310509
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Nephrology Dialysis Transplantation
- Accession number :
- edsair.doi.dedup.....d8e67b32e7a6aae3ee5d1c1550b4be7e