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Broccoli extract improves high fat diet-induced obesity, hepatic steatosis and glucose intolerance in Wistar rats
- Source :
- Journal of Functional Foods, Vol 59, Iss, Pp 319-328 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Brassicaceae contain bioactive compounds with potential positive effects on metabolic syndrome. Here, we evaluated the eventual anti-obesity properties of an ethanolic broccoli extract (BE), selected by a tested ability to reduce Caenorhabditis elegans fat content. Two doses (14 and 140 mg/kg animal) of BE were evaluated in a diet-induced obesity (DIO) Wistar rat model. After 10 weeks of BE supplementation, animals exhibited reduced body weight gain and food efficiency, decreased atherogenic index of plasma and improved glucose tolerance in comparison with non-supplemented rats. BE also reduced the retroperitoneal fat mass and adipocyte size, all associated to down-regulation of Cebpa, Srebp1, Fasn and Adipoq expression in adipocytes. Finally, BE significantly decreased liver steatosis, accompanied by the up-regulation of Acot8 and Acox1, and the down-regulation of Fasn, Fatp4 and Srebf1 expression in hepatocytes. Our data provides new knowledge about the potential role of broccoli components in the prevention of metabolic syndrome.
- Subjects :
- medicine.medical_specialty
Glucosinolates
Medicine (miscellaneous)
Bioactive compounds
High fat diet induced obesity
chemistry.chemical_compound
Fatty liver
Adipocyte
Internal medicine
CEBPA
medicine
TX341-641
Srebf1
Nutrition and Dietetics
Nutrition. Foods and food supply
Insulin resistance
medicine.disease
Obesity
Sterol regulatory element-binding protein
Endocrinology
chemistry
C. elegans
ACOX1
Steatosis
Metabolic syndrome
Food Science
Subjects
Details
- ISSN :
- 17564646
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....d8e59c97c0d96f8f0988ddfebdd28eb6