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The Synergy of Topographical Micropatterning and Ta|TaCu Bilayered Thin Film on Titanium Implants Enables Dual-Functions of Enhanced Osteogenesis and Anti-Infection
- Source :
- Advanced healthcare materials. 10(9)
- Publication Year :
- 2021
-
Abstract
- Poor osteogenesis and implant-associated infection are the two leading causes of failure for dental and orthopedic implants. Surface design with enhanced osteogenesis often fails in antibacterial activity, or vice versa. Herein, a surface design strategy, which overcomes this trade-off via the synergistic effects of topographical micropatterning and a bilayered nanostructured metallic thin film is presented. A specific microgrooved pattern is fabricated on the titanium surface, followed by sequential deposition of a nanostructured copper (Cu)-containing tantalum (Ta) (TaCu) layer and a pure Ta cap layer. The microgrooved patterns coupled with the nanorough Ta cap layer shows strong contact guidance to preosteoblasts and significantly enhances the osteogenic differentiation in vitro, while the controlled local sustained release of Cu ions is responsible for high antibacterial activity. Importantly, rat calvarial defect models in vivo further confirm that the synergy of microgrooved patterns and the Ta|TaCu bilayered thin film on titanium surface could effectively promote bone regeneration. The present effective and versatile surface design strategy provides significant insight into intelligent surface engineering that can control biological response at the site of healing in dental and orthopedic implants.
- Subjects :
- Materials science
Surface Properties
Biomedical Engineering
Tantalum
Pharmaceutical Science
chemistry.chemical_element
02 engineering and technology
Surface engineering
010402 general chemistry
01 natural sciences
Biomaterials
Osteogenesis
Anti infectives
Animals
Thin film
Bone regeneration
Titanium
Prostheses and Implants
021001 nanoscience & nanotechnology
0104 chemical sciences
Rats
chemistry
0210 nano-technology
Layer (electronics)
Biomedical engineering
Micropatterning
Subjects
Details
- ISSN :
- 21922659
- Volume :
- 10
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Advanced healthcare materials
- Accession number :
- edsair.doi.dedup.....d8e3bf0715468d8d00152e5eebeaf227