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Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin
- Source :
- Experimental Animals
- Publication Year :
- 2015
- Publisher :
- Japanese Association for Laboratory Animal Science, 2015.
-
Abstract
- The spontaneously diabetic torii (SDT) fatty rat is a new model of type 2 diabetes showing overt obesity, hyperglycemia and hyperlipidemia. With early onset of diabetes mellitus, diabetic microvascular complications, including nephropathy, peripheral neuropathy and retinopathy, are observed at young ages. In the present study, blood glucose levels of female SDT fatty rats were controlled with phlorizin, a non-selective SGLT inhibitor, to examine whether and how these complications are caused by hyperglycemia. Phlorizin treatment adequately controlled plasma glucose levels during the experiment. At 29 weeks of age, urinary albumin excretion considerably increased in SDT fatty rats. Glomerulosclerosis and tubular pathological findings also indicate diabetic nephropathy. These renal parameters tended to decrease with phlorizin; however, effects were partial. Sciatic nerve conduction velocities were significantly delayed in SDT fatty rats compared with Sprague-Dawley (SD) rats. Intraepidermal nerve fiber density, an indicator of subclinical small nerve fiber neuropathy, significantly decreased in SDT fatty rats. Retinal dysfunction (prolongation of peak latency for oscillatory potential in electroretinograms) and histopathological eye abnormalities, including retinal folding and mature cataracts were also observed. Both nerve and eye disorders were prevented with phlorizin. These findings indicate that severe hyperglycemia mainly causes diabetic complications in SDT fatty rats. However, other factors, such as hyperlipidemia and hypertension, may affect diabetic nephropathy. These characteristics of diabetic complications will become helpful in evaluating new drugs for diabetic complications using SDT fatty rats.
- Subjects :
- Blood Glucose
medicine.medical_specialty
peripheral neuropathy
Original
Phlorizin
Type 2 diabetes
SDT fatty rat
Sodium-Glucose Transport Proteins
General Biochemistry, Genetics and Molecular Biology
Diabetes Mellitus, Experimental
Nephropathy
Diabetes Complications
Rats, Sprague-Dawley
Diabetic nephropathy
chemistry.chemical_compound
Diabetic Neuropathies
Diabetes mellitus
Internal medicine
retinopathy
Hyperlipidemia
diabetic complications
medicine
Albuminuria
Animals
Diabetic Nephropathies
Diabetic Retinopathy
General Veterinary
business.industry
Rats, Inbred Strains
General Medicine
medicine.disease
Disease Models, Animal
Kidney Tubules
Phlorhizin
Endocrinology
Peripheral neuropathy
Diabetes Mellitus, Type 2
chemistry
Hyperglycemia
nephropathy
Eye disorder
Female
Animal Science and Zoology
business
Subjects
Details
- ISSN :
- 18817122 and 13411357
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Experimental Animals
- Accession number :
- edsair.doi.dedup.....d8cfd205a390f37f79f2e16209c6c2b7