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Serum salusin-β in relation to atherosclerosis and ventricular dysfunction in patients with type 2 diabetes mellitus
- Source :
- Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 14:2057-2062
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Salusin-β is a newly defined biomarker that plays a role in atherogenesis and in homeostasis. The study aimed to assess serum salusin-β level in relation to atherosclerosis and ventricular dysfunction in type 2 diabetes mellitus (T2DM) patients.Sixty T2DM patients and twenty-five age-matched healthy controls were included. Serum salusin-β was determined by ELISA. Echocardiography and carotid ultrasonography were carried out for all individuals.Serum salusin-β level was significantly elevated in patients with T2DM than in controls (P 0.001). It was positively correlated with obesity parameters, insulin resistance index (r = 0.280,P 0.001), atherogenic dyslipidemia and with carotid intima media thickness (CIMT) (r = 0.411, P 0.001). Echocardiographic findings showed a positive correlation between salusin-β and left ventricular hypertrophy (LVH) parameters and a negative correlation with left ventricular (LV) diastolic and systolic functions. Regression analysis showed that serum salusin-β level was a significant predictor of diastolic dysfunction.Serum salusin-β may be associated with atherosclerosis and LV dysfunction in T2DM.
- Subjects :
- Male
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Type 2 diabetes
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
Ventricular Dysfunction, Left
03 medical and health sciences
0302 clinical medicine
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
In patient
030212 general & internal medicine
business.industry
Carotid ultrasonography
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
General Medicine
Middle Aged
Atherosclerosis
Prognosis
medicine.disease
Salusin β
Diabetes Mellitus, Type 2
Case-Control Studies
Cardiology
Intercellular Signaling Peptides and Proteins
Biomarker (medicine)
Female
Insulin Resistance
business
Biomarkers
Homeostasis
Follow-Up Studies
Subjects
Details
- ISSN :
- 18714021
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Diabetes & Metabolic Syndrome: Clinical Research & Reviews
- Accession number :
- edsair.doi.dedup.....d8cbc565183333b542fb93361b57ed0b