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Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome
- Source :
- Cardiovascular Diabetology, Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-11 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background The triglyceride-glucose index (TyG index) has been regarded as a reliable alternative marker of insulin resistance and an independent predictor of cardiovascular outcomes. Whether the TyG index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome (ACS) remains uncertain. The aim of this study was to investigate the prognostic value of the TyG index in patients with diabetes and ACS. Methods A total of 2531 consecutive patients with diabetes who underwent coronary angiography for ACS were enrolled in this study. Patients were divided into tertiles according to their TyG index. The primary outcomes included the occurrence of major adverse cardiovascular events (MACEs), defined as all-cause death, non-fatal myocardial infarction and non-fatal stroke. The TyG index was calculated as the ln (fasting triglyceride level [mg/dL] × fasting glucose level [mg/dL]/2). Results The incidence of MACE increased with TyG index tertiles at a 3-year follow-up. The Kaplan–Meier curves showed significant differences in event-free survival rates among TyG index tertiles (P = 0.005). Multivariate Cox hazards regression analysis revealed that the TyG index was an independent predictor of MACE (95% CI 1.201–1.746; P Conclusions The TyG index predicts future MACE in patients with diabetes and ACS independently of known cardiovascular risk factors, suggesting that the TyG index may be a useful marker for risk stratification and prognosis in patients with diabetes and ACS.
- Subjects :
- Blood Glucose
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
China
Acute coronary syndrome
medicine.medical_specialty
Time Factors
Endocrinology, Diabetes and Metabolism
Coronary Angiography
Risk Assessment
Triglyceride-glucose index
Cardiovascular events
Insulin resistance
Predictive Value of Tests
Risk Factors
Diabetes mellitus
Internal medicine
Diabetes Mellitus
medicine
Humans
Myocardial infarction
Stroke
Triglycerides
Original Investigation
Aged
Retrospective Studies
Angiology
business.industry
Incidence
Diabetes
Area under the curve
Middle Aged
medicine.disease
Progression-Free Survival
lcsh:RC666-701
Disease Progression
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Mace
Subjects
Details
- ISSN :
- 14752840
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Diabetology
- Accession number :
- edsair.doi.dedup.....d8bb31880a615690444ea6a5dd5cee7c