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O6-Alkylguanine-DNA alkyltransferase activity in schistosomiasis-associated human bladder cancer
- Source :
- European Journal of Cancer. 30:1314-1319
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- O6-Alkylguanine-DNA-alkyltransferase (ATase) activity was measured in extracts of 55 bladder tissue samples (46 tumour and nine uninvolved mucosal tissue) from Egyptian patients with schistosome-associated bladder carcinoma. Activity varied from 2.0 to 16.2 fmole ATase/microgram DNA (mean +/- S.D.; 5.6 +/- 4.0) or from 28 to 351 fmole ATase/mg (117 +/- 71). ATase levels in schistosome-associated bladder cancer tissues (5.6 +/- 4.0 fmole ATase/microgram DNA) tended to be lower than those observed in normal human bladder mucosal tissue (8.5 +/- 4.4 fmole ATase/microgram DNA). In a previous study (Badawi et al., Carcinogenesis, 1992, 13, 877-881) DNA-alkylation damage (O6-methyldeoxyguanosine) was found in 44/46 of these schistosome-associated bladder cancer samples at levels ranging from 0.012 to 0.485 mumole O6-MedG/mole deoxyguanosine. We now report an inverse correlation between the levels of methylation damage and ATase activity (r = -0.67; P0.001). These observations encourage further investigations of the possible role of environmental alkylating agents in the aetiology of early bladder cancer associated with schistosomiasis.
- Subjects :
- Male
Cancer Research
Pathology
medicine.medical_specialty
Urinary Bladder
Schistosomiasis
Biology
medicine.disease_cause
O(6)-Methylguanine-DNA Methyltransferase
Schistosomiasis haematobia
chemistry.chemical_compound
medicine
Carcinoma
Humans
Deoxyguanosine
Bladder cancer
Urinary bladder
Epithelioma
Cancer
DNA, Neoplasm
Methyltransferases
medicine.disease
Neoplasm Proteins
medicine.anatomical_structure
Urinary Bladder Neoplasms
Oncology
chemistry
Cancer research
Female
Carcinogenesis
Subjects
Details
- ISSN :
- 09598049
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- European Journal of Cancer
- Accession number :
- edsair.doi.dedup.....d8acd21b91790bbe1577fc77894dc0b5