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Mapping Migraine-Specific Quality of Life to Health State Utilities in Patients Receiving Rimegepant
- Source :
- Advances in Therapy
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Introduction Migraine is a debilitating neurological condition, affecting up to 15% of Americans. Recent estimates from a long-term safety study of rimegepant showed evidence of decreased monthly migraine days (MMD) in people with episodic migraine treated with rimegepant 75 mg. The objective of this study was to characterize migraine-specific quality of life version 2.1 (MSQv2) scores and corresponding mapped EuroQol-5 Dimensions-3 Level (EQ-5D-3L) utility values. Methods Study participants were randomized into two treatment regimens: individuals with 2–14 MMD received rimegepant 75 mg as needed (PRN), and those with 4–14 MMD at baseline who received rimegepant on a fixed every-other-day schedule plus an as needed dose on days they did not treat (QOD + PRN). MSQv2 was mapped to EQ-5D-3L utilities using a validated algorithm. Outcomes were assessed for the PRN arm at baseline weeks 12, 24, 36, and 52 and for the QOD + PRN arm at baseline and week 12. Results At baseline, MSQv2 data were available for 1,800 patients: 1,033 with 2–8 MMD in the PRN group, 481 with 9–14 MMD in the PRN group, and 286 with 4–14 MMD in the QOD + PRN group. For all MSQv2 domains as well as mapped utility values, outcomes improved over each study visit. At baseline, EQ-5D-3L utilities were 0.66, 0.63, and 0.65 for the 2–8 MMD PRN, 9–14 MMD PRN, and 4–14 MMD QOD + PRN groups, respectively. At end-of-study, utilities had increased by + 0.09, + 0.10, and + 0.12 for the three groups, respectively (p
- Subjects :
- medicine.medical_specialty
Pyridines
Health Status
Migraine Disorders
Utility
Piperidines
Quality of life
EQ-5D
Surveys and Questionnaires
Internal medicine
medicine
Humans
Pharmacology (medical)
In patient
Migraine
Patient-reported outcome
Migraine-specific quality of life (MSQv2)
Original Research
business.industry
Migraine Specific Quality of Life
General Medicine
medicine.disease
Rheumatology
Clinical trial
Preference-based instrument
Mapping
Quality of Life
business
Algorithms
Subjects
Details
- ISSN :
- 18658652 and 0741238X
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Advances in Therapy
- Accession number :
- edsair.doi.dedup.....d894cb5c522ea2f58585742842f05627