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The Relevance of MicroRNAs in the Pathogenesis and Prognosis of HCV-Disease: The Emergent Role of miR-17-92 in Cryoglobulinemic Vasculitis
- Source :
- Viruses, Volume 12, Issue 12, Viruses, Vol 12, Iss 1364, p 1364 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- Hepatitis C virus (HCV) is a major public health problem. HCV is a hepatotropic and lymphotropic virus that leads to hepatocellular carcinoma (HCC) and lymphoproliferative disorders such as cryoglobulinemic vasculitis (CV) and non-Hodgkin&rsquo<br />s lymphoma (NHL). The molecular mechanisms by which HCV induces these diseases are not fully understood. MicroRNAs (miRNAs) are small non-coding molecules that negatively regulate post-transcriptional gene expression by decreasing their target gene expression. We will attempt to summarize the current knowledge on the role of miRNAs in the HCV life cycle, HCV-related HCC, and lymphoproliferative disorders, focusing on both the functional effects of their deregulation as well as on their putative role as biomarkers, based on association analyses. We will also provide original new data regarding the miR 17-92 cluster in chronically infected HCV patients with and without lymphoproliferative disorders who underwent antiviral therapy. All of the cluster members were significantly upregulated in CV patients compared to patients without CV and significantly decreased in those who achieved vasculitis clinical remission after viral eradication. To conclude, miRNAs play an important role in HCV infection and related oncogenic processes, but their molecular pathways are not completely clear. In some cases, they may be potential therapeutic targets or non-invasive biomarkers of tumor progression.
- Subjects :
- Male
0301 basic medicine
Lymphoma
viruses
lcsh:QR1-502
Hepacivirus
Disease
medicine.disease_cause
lcsh:Microbiology
0302 clinical medicine
miR 17-92
HCC
Liver Neoplasms
virus diseases
Middle Aged
Prognosis
Hepatitis C
Cell Transformation, Neoplastic
Infectious Diseases
Cryoglobulinemia
030220 oncology & carcinogenesis
Host-Pathogen Interactions
HCV
cryoglobulinemic vasculitis
Female
RNA, Long Noncoding
Disease Susceptibility
Vasculitis
Carcinoma, Hepatocellular
Genotype
Hepatitis C virus
Lymphoproliferative disorders
NHL
Article
Virus
03 medical and health sciences
MIRNAs
Virology
medicine
Humans
Cryoglobulinemic vasculitis
Aged
business.industry
medicine.disease
Lymphoproliferative Disorders
digestive system diseases
MicroRNAs
030104 developmental biology
Tumor progression
Immunology
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....d894b16591ba30041f4f1c5947650f20
- Full Text :
- https://doi.org/10.3390/v12121364