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Use of tuberculin skin test for assessment of immune recovery among previously malnourished children in Ethiopia
- Source :
- BMC Research Notes, Vol 10, Iss 1, Pp 1-7 (2017), BMC research notes, 10 (1, BMC Research Notes
- Publication Year :
- 2017
- Publisher :
- BMC, 2017.
-
Abstract
- Objective: To compare levels of immunity in children recovering from severe acute malnutrition (cases) against those of community controls (controls). Results: At baseline children recovering from severe acute malnutrition had lower, mid upper arm circumference (122 mm for cases and 135 mm for controls; p < 0.001), weight-for-height Z-score (- 1.0 for cases and - 0.5 for controls; p < 0.001), weight-for-age Z-score (- 2.8 for cases and - 1.1 for controls; p < 0.001) and height/length-for-age Z-score (- 3.6 for cases and - 1.4 for controls; p < 0.001), than controls. Age and gender matched community controls. At baseline, prevalence of a positive tuberculin skin test, assessed by cutaneous delayed-type hypersensitivity reaction skin test, was very low in both cases (3/93 = 3.2%) and controls (2/94 = 2.1%) and did not significantly increase at 6 months follow up (6/86 = 7.0% in cases and 3/84 = 3.4% in controls). The incidences of common childhood morbidities, namely fever, diarrhoea and cough, were 1.7-1.8 times higher among cases than controls. In conclusion, these results show that tuberculin skin test does not enable any conclusive statements regarding the immune status of patients following treatment for severe acute malnutrition. The increased incidence of infection in cases compared to controls suggests persistence of lower resistance to infection even after anthropometric recovery is achieved.<br />SCOPUS: ar.j<br />info:eu-repo/semantics/published
- Subjects :
- Male
medicine.medical_specialty
Severe Acute Malnutrition
Delayed-type hypersensitivity response
Tuberculin
Aftercare
lcsh:Medicine
Child Nutrition Disorders
Severity of Illness Index
General Biochemistry, Genetics and Molecular Biology
Persistence (computer science)
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Internal medicine
Severity of illness
medicine
Body Size
Humans
030212 general & internal medicine
lcsh:Science (General)
lcsh:QH301-705.5
Tuberculin purified protein derivative
Tuberculin skin test
business.industry
Tuberculin Test
Incidence (epidemiology)
lcsh:R
Immunity
Infant
Community-based management of acute malnutrition
General Medicine
Skin test
Anthropometry
Sciences bio-médicales et agricoles
Surgery
Hypersensitivity reaction
Research Note
lcsh:Biology (General)
Severe acute malnutrition
Child, Preschool
Female
Ethiopia
Morbidity
business
Biologie
lcsh:Q1-390
Subjects
Details
- Language :
- English
- ISSN :
- 17560500
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Research Notes
- Accession number :
- edsair.doi.dedup.....d882d34b33b00da0af650fa81fd69b43
- Full Text :
- https://doi.org/10.1186/s13104-017-2909-x