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Follicular tumors of the thyroid gland: Diagnosis, clinical aspects and nuclear DNA analysis
- Source :
- World Journal of Surgery. 16:589-594
- Publication Year :
- 1992
- Publisher :
- Springer Science and Business Media LLC, 1992.
-
Abstract
- From 1985 to 1990, 169 patients underwent surgery for follicular thyroid tumors at the Department of Surgery, Karolinska Hospital, Stockholm, Sweden. Nine of the patients had tumors which were diagnosed as follicular carcinoma, 4 of whom had recurrences in the neck region. In 6 of the patients the carcinomas were diagnosed as widely invasive and in 3 patients as minimally invasive. Of the 160 patients with follicular adenomas, 21 adenomas were of oxyphil type ("Hürthle" adenomas), 17 adenomas were diagnosed as "atypical", and 6 adenomas were classified as being both "atypical" and having oxyphil cell differentiation. The nuclear DNA content was measured with image cytometry and/or flow cytometry. Six of the 9 carcinomas were euploid and 3 were aneuploid. In the adenoma group, 32 (20%) were aneuploid. Thus 38% of all adenomas showed atypical cellular features, oxyphil cell differentiation, and/or aneuploid nuclear DNA pattern. None of the patients with adenomas have shown any sign of recurrence. In the present prospective study, the nuclear DNA content could not discriminate between a benign and a malignant follicular tumor, and was of limited value in predicting prognosis in the patients with follicular carcinoma. Still, the best way to establish a diagnosis and to predict prognosis is to surgically remove the follicular tumor for a proper histopathological examination.
- Subjects :
- Adenoma
Adult
Male
Pathology
medicine.medical_specialty
Adolescent
Adenocarcinoma
Follicular phase
Image Processing, Computer-Assisted
medicine
Humans
Prospective Studies
Thyroid Neoplasms
Prospective cohort study
Aged
Aged, 80 and over
business.industry
Thyroid
DNA, Neoplasm
Middle Aged
Flow Cytometry
medicine.disease
stomatognathic diseases
medicine.anatomical_structure
Cardiothoracic surgery
Oxyphil cell (pathology)
Image Cytometry
Female
Surgery
business
Abdominal surgery
Subjects
Details
- ISSN :
- 14322323 and 03642313
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- World Journal of Surgery
- Accession number :
- edsair.doi.dedup.....d867f7dd11a5b7d06d532acc7020ff68