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Brexanolone (Zulresso): Finally, an FDA-Approved Treatment for Postpartum Depression
- Source :
- Annals of Pharmacotherapy. 54:157-163
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- Objective: To review the safety and efficacy of brexanolone for the treatment of moderate to severe postpartum depression (PPD). Data Sources: A literature search through PubMed was conducted (January 2012 to July 2019) using the keyword brexanolone for clinical trials published in the English language. Study Selection and Data Extraction: Articles were selected if they were related to the Food and Drug Administration (FDA) approval of brexanolone or provided novel clinical information regarding this drug entity. Data Synthesis: The findings of the review show that brexanolone administered via IV infusion is both an effective and a fairly safe option for the treatment of PPD. Relevance to Patient Care and Clinical Practice: There are several antidepressants currently used to treat PPD; however, this is the first with FDA approval for this indication. The rapid onset of action of brexanolone may offer a quicker relief of these symptoms and may possibly lead to improved quality of life for both the mother and the child. Conclusion and Relevance: The recent FDA approval of brexanolone may offer an effective treatment of moderate to severe PPD and has been shown to rapidly decrease depression symptoms.
- Subjects :
- Drug
Postpartum depression
medicine.medical_specialty
IV Infusion
media_common.quotation_subject
Pregnanolone
Severity of Illness Index
Depression, Postpartum
03 medical and health sciences
0302 clinical medicine
Quality of life (healthcare)
medicine
Humans
Effective treatment
Pharmacology (medical)
030212 general & internal medicine
Infusions, Intravenous
Intensive care medicine
Depression (differential diagnoses)
media_common
Clinical Trials as Topic
United States Food and Drug Administration
business.industry
beta-Cyclodextrins
medicine.disease
Antidepressive Agents
United States
Clinical trial
Drug Combinations
Treatment Outcome
Data extraction
Quality of Life
Female
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15426270 and 10600280
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Annals of Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....d853960c92e50ef0ee56a913aa46706c