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HER2-expressing breast tumors are associated with breast cancer stem-cell phenotype CD44+/CD24
- Source :
- Jornal Brasileiro de Patologia e Medicina Laboratorial v.54 n.5 2018, Jornal Brasileiro de Patologia e Medicina Laboratorial, Sociedade Brasileira de Patologia (SBP), instacron:SBP, Jornal Brasileiro de Patologia e Medicina Laboratorial, Vol 54, Iss 5, Pp 310-318 (2018)
- Publication Year :
- 2018
- Publisher :
- Sociedade Brasileira de Patologia Clínica, 2018.
-
Abstract
- INTRODUCTION: According to the cancer stem-cell theory, tumors originate from a small population of cancer stem cells, which lose the mechanism of self-regulation and begin to differentiate and proliferate indefinitely. The CD44+/CD24- phenotype may be considered a stem-cell marker in breast cancer. OBJECTIVE: To evaluate the correlation between CD44+/CD24- phenotype and different molecular subtypes of breast cancer in invasive ductal carcinoma samples. METHODS: The expression of CD44, CD44v6, and CD24 markers was investigated in 133 cases of invasive mammary carcinoma with immunohistochemistry. CD44+/CD24- phenotype was identified and correlated with the molecular subtypes and classical prognostic factors such as age, histological grade, tumor size, and lymph node status. RESULTS: Eighteen (14%) cases were positive for CD44+/CD24- (CD44+/CD24- or CD44v6+/CD24-) phenotype; among these, 11.1%, 27.8%, 38.9%, and 22.2% were luminal, luminal B-human epidermal growth factor receptor 2 (HER2), HER2, and triple-negative subtype, respectively. CD44+/ CD24- phenotype was more common in HER2 subgroup (p = 0.0197). CONCLUSION: CD44+/CD24- phenotype was correlated with molecular subtypes of breast cancer. The highest expression of CD44+/CD24- phenotype was reported in patients with HER2+ disease, a molecular subtype associated with more aggressive behavior and worse prognosis.
- Subjects :
- 0301 basic medicine
Clinical Biochemistry
Population
Pathology and Forensic Medicine
03 medical and health sciences
Breast cancer
Cancer stem cell
medicine
Pathology
breast neoplasms
RB1-214
Epidermal growth factor receptor
education
skin and connective tissue diseases
Lymph node
education.field_of_study
biology
business.industry
neoplastic stem cells
CD44
Cancer
medicine.disease
Phenotype
Medical Laboratory Technology
030104 developmental biology
medicine.anatomical_structure
breast ductal carcinoma
CD44 antigens
Cancer research
biology.protein
business
CD24 antigens
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Jornal Brasileiro de Patologia e Medicina Laboratorial v.54 n.5 2018, Jornal Brasileiro de Patologia e Medicina Laboratorial, Sociedade Brasileira de Patologia (SBP), instacron:SBP, Jornal Brasileiro de Patologia e Medicina Laboratorial, Vol 54, Iss 5, Pp 310-318 (2018)
- Accession number :
- edsair.doi.dedup.....d8528ccfb29f9dab43302fc310627113