Back to Search
Start Over
Role of TGF-β signalling in PCOS associated focal segmental glomerulosclerosis
- Source :
- Clinica Chimica Acta. 510:244-251
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Research on polycystic ovarian syndrome (PCOS) remains intense due to its evolving impact on metabolism, reproduction and cardiovascular function. Changes in metabolic pathways can also significantly impact renal function including the development of Focal Segmental Glomerulosclerosis (FSGS), one of the most highly investigated renal diseases. In FSGS, scarring of the glomerulus vascular tuft damages the kidneys. Onset of FSGS may either be congenital or due to other disorders that affect the metabolism and normal kidney function. Both PCOS and FSGS appear to be associated with Transforming Growth Factor-β (TGF-β) signalling. Over-expression of TGF-β may be due to the activation of the thrombospondin 1 (TSP1) gene, which increases the probability of developing renal disorders. Higher androgen levels in PCOS may also cause podocyte damage thus directly impacting development of FSGS. This article reviews the role of TGF-β's in PCOS and FSGS and explores the inter-relationship between these two disorders.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
medicine.drug_class
Kidney Glomerulus
Clinical Biochemistry
Renal function
urologic and male genital diseases
Biochemistry
Podocyte
03 medical and health sciences
0302 clinical medicine
Focal segmental glomerulosclerosis
Transforming Growth Factor beta
Internal medicine
Thrombospondin 1
Humans
Medicine
Tgf β signalling
RENAL DISORDERS
Glomerulosclerosis, Focal Segmental
Podocytes
urogenital system
business.industry
Biochemistry (medical)
General Medicine
Androgen
medicine.disease
female genital diseases and pregnancy complications
030104 developmental biology
Endocrinology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
business
Polycystic Ovary Syndrome
Transforming growth factor
Subjects
Details
- ISSN :
- 00098981
- Volume :
- 510
- Database :
- OpenAIRE
- Journal :
- Clinica Chimica Acta
- Accession number :
- edsair.doi.dedup.....d84d98e1ad7ad21b7178a1b7748832d0