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Effect of a resin-modified calcium silicate cement on inflammatory cell infiltration and reparative dentin formation after pulpotomy in rat molars
- Source :
- Australian endodontic journal : the journal of the Australian Society of Endodontology IncReferences. 48(2)
- Publication Year :
- 2021
-
Abstract
- Resin monomers and polymerisation initiators have been shown to be cytotoxic for pulp cells and to disturb odontoblast differentiation. This study aimed to compare the effect of a resin-modified calcium silicate cement (TheraCal LC; TC) and a resin-free calcium silicate cement (ProRoot MTA; PR) on pulpal healing after pulpotomy. Pulpotomy was performed on the maxillary first molars of 8-week-old rats using either PR or TC. After 1, 3, 7, 14 and 28 days, pulpal responses were assessed by micro-computed tomography, haematoxylin-eosin staining and immunostaining against CD68, which is a pan-macrophage marker. The results showed that pulpotomy with TC induced persistent infiltration of inflammatory cells, including CD68-positive macrophages, and delayed the formation of reparative dentin as compared with that with PR, although both materials allowed pulpal healing over the long term. Therefore, resin-modified TC was not as biocompatible nor bioinductive as resin-free PR when applied on the healthy pulp of rat molars.
- Subjects :
- Molar
Pulpotomy
Dentistry
Odontoblast differentiation
Dentin, Secondary
chemistry.chemical_compound
stomatognathic system
medicine
Animals
Aluminum Compounds
General Dentistry
Dental Pulp
Cement
Chemistry
business.industry
Silicates
Oxides
X-Ray Microtomography
Calcium Compounds
medicine.disease
Rats
Resin Cements
Drug Combinations
Calcium silicate
Pulp (tooth)
business
Infiltration (medical)
Immunostaining
Subjects
Details
- ISSN :
- 17474477
- Volume :
- 48
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Australian endodontic journal : the journal of the Australian Society of Endodontology IncReferences
- Accession number :
- edsair.doi.dedup.....d8478fc290dffbec9eccd0e4aed29667