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Sex-Dependent Effects of Developmental Lead Exposure in Wistar Rats: Evidence from Behavioral and Molecular Correlates
- Source :
- International Journal of Molecular Sciences, Volume 21, Issue 8, International Journal of Molecular Sciences, Vol 21, Iss 2664, p 2664 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- Lead (Pb) exposure in early life affects brain development resulting in cognitive and behavioral deficits. Epidemiologic and experimental evidence of sex as an effect modifier of developmental Pb exposure is emerging. In the present study, we investigated Pb effects on behavior and mechanisms of neuroplasticity in the hippocampus and potential sex differences. To this aim, dams were exposed, from one month pre-mating to offspring weaning, to Pb via drinking water at 5 mg/kg body weight per day. In the offspring of both sexes, the longitudinal assessment of motor, emotional, and cognitive end points was performed. We also evaluated the expression and synaptic distribution of N-methyl-D-Aspartate receptor (NMDA) and &alpha<br />amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits at post-natal day (pnd) 23 and 70 in the hippocampus. Neonatal motor patterns and explorative behavior in offspring were affected in both sexes. Pb effects in emotional response and memory retention were observed in adult females only, preceded by increased levels of GluN2A and GluA1 subunits at the post-synapse at pnd 23. These data suggest that Pb exposure during development affects glutamatergic receptors distribution at the post-synaptic spine in females. These effects may contribute to alterations in selected behavioral domains.
- Subjects :
- 0301 basic medicine
Male
Developmental Disabilities
Hippocampus
lcsh:Chemistry
0302 clinical medicine
lcsh:QH301-705.5
Spectroscopy
glutamatergic receptors
Sex Characteristics
Neuronal Plasticity
Behavior, Animal
neurodevelopment
Mental Disorders
Brain
General Medicine
Computer Science Applications
Receptors, Glutamate
NMDA receptor
Female
Disease Susceptibility
medicine.medical_specialty
Offspring
neuroplasticity
AMPA receptor
Biology
Receptors, N-Methyl-D-Aspartate
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
Glutamatergic
Internal medicine
Neuroplasticity
medicine
Weaning
Animals
Physical and Theoretical Chemistry
Molecular Biology
lead
behavior
Organic Chemistry
Environmental Exposure
Rats
Sexual dimorphism
Disease Models, Animal
030104 developmental biology
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
sexual dimorphism
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....d82d390fe8307d7a8347b1bb2e67cdb1
- Full Text :
- https://doi.org/10.3390/ijms21082664